Uterine Fibroid Liquefaction: A Guide for Women - Obstetrics and Gynecology

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Liquefaction of uterine fibroids


Hello Dr.
Huang, I am an unmarried woman with no sexual experience.
Around the year 2011, I underwent a gynecological ultrasound due to irregular menstruation and was informed that I had three uterine fibroids measuring 3 cm, 3 cm, and 4 cm.
I started taking progesterone to regulate my menstrual cycle, and after my periods became normal, I stopped the medication.
Upon follow-up ultrasound, the sizes were reduced to 2.5 cm, 2.5 cm, and 2.5 cm.
About a year later, during another ultrasound, the doctor informed me that two of the fibroids had merged into one, measuring 4 cm and 2 cm.
In March of this year, the measurements were 5 cm and 2 cm.
Today, I went for a follow-up, and the details are as follows:
GYN Sonar findings:
Mode: Transabdominal (v) Transvaginal ( )
Uterus position: anteverted
Size: enlarged 5 x 5 x 6 cm³
Mass: myomatous nodule about 3.6 cm in diameter and other small ones about 1 cm
Endometrium: small degenerative changes about 1 cm
The doctor told me that the largest fibroid is about 3 cm, with a few smaller ones, totaling around 2 or 3.
Additionally, the ovaries are slightly enlarged, and there is some liquefaction of the uterine fibroids.
When I asked if this was serious, he casually mentioned that I shouldn't worry since I am already postmenopausal.
I inquired about any abnormalities in the endometrium, and he said there is no endometrium since I no longer have periods.
I have some concerns, so I came to seek your advice.
Thank you, esteemed doctor.

Er Mao, 50~59 year old female. Ask Date: 2017/11/29

Dr. Huang Jianzhong reply Obstetrics and Gynecology


It should be fine.

Reply Date: 2017/11/29

More Info


Understanding uterine fibroids, particularly in the context of liquefaction, is crucial for women, especially those who are experiencing symptoms or have been diagnosed with fibroids. Uterine fibroids, or leiomyomas, are benign tumors that develop from the smooth muscle tissue of the uterus. They can vary in size, number, and location, and while many women with fibroids experience no symptoms, others may face complications.

From your description, it appears that you have been monitored for fibroids over several years, with changes in size noted during ultrasound examinations. The fact that you have multiple fibroids, with the largest measuring around 5 cm, is significant. The mention of "liquefaction" indicates that some of the fibroids may be undergoing degeneration, which can occur when the blood supply to the fibroid is compromised. This process can lead to changes in the fibroid's structure, sometimes resulting in a cystic appearance on imaging studies.

Your doctor’s reassurance that you should not worry too much, especially since you are approaching menopause, is based on the understanding that fibroids often shrink after menopause due to decreased estrogen levels. However, it is essential to monitor any changes in symptoms or the size of the fibroids, as they can sometimes lead to complications such as heavy bleeding, pelvic pain, or pressure symptoms.

Regarding your concerns about the endometrium, it is understandable to be apprehensive, especially if you have not had a menstrual period for some time. The endometrium, or the lining of the uterus, typically undergoes changes in response to hormonal fluctuations. In postmenopausal women, the endometrium usually thins out due to the lack of estrogen. However, if there are any concerns about abnormal thickening or other changes, further evaluation may be warranted, such as an endometrial biopsy, to rule out any potential issues.

It is also worth noting that while fibroids are generally benign, they can sometimes lead to complications, particularly if they grow large or if they are located in a position that interferes with normal uterine function. If you experience any new symptoms, such as significant pelvic pain, changes in urinary or bowel habits, or any unusual bleeding, it is essential to consult your healthcare provider promptly.

In summary, while your current situation with fibroids and the associated liquefaction may not be immediately concerning, ongoing monitoring and communication with your healthcare provider are crucial. They can provide personalized advice based on your specific circumstances and help you navigate any potential risks or changes in your health. If you have further questions or concerns, do not hesitate to reach out for more information or clarification.

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