PSA Levels and Prostate Health: Key Questions Answered - Urology

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PSA testing and prostate examination issues?


Hello, I recently had a health check at my company and would like to ask the following questions:
1.
My PSA level is 2.93 ng/ml, and the report indicates that the normal range is 0-2.39.
Last year, my PSA was 1.26.
I understand that different laboratories may have varying reference ranges, but I found online that the normal range is often cited as 0-4.
The report from last year also stated a normal range of 0-4.
Are there different testing methods for PSA that could lead to discrepancies in the normal range? Or is the increase in my value significant enough to be flagged as abnormal? Is there a possibility that lifestyle adjustments or other methods could help return this value to normal?
2.
Currently, I occasionally experience nocturia once a night, though sometimes not at all; I also sometimes feel a bit of urgency and notice that my urine volume can be slightly low.
At times, I feel like I have incomplete bladder emptying.
I have previously visited a urologist due to concerns about potential benign prostatic hyperplasia or other conditions, but the doctor dismissed my concerns due to my young age and did not perform a digital rectal exam.
Additionally, I masturbate nearly every day; how might this affect my prostate or PSA levels? (I recall that I may have masturbated the night before the test.) Should I consider undergoing any further examinations?
3.
My creatinine level is 1.34 mg/dl (normal range is 0.9-1.3 mg/dl).
This value is slightly elevated; what should I be aware of regarding this?
4.
My glomerular filtration rate (GFR) is 66.08, with no protein in the urine.
Although this is considered normal, my values have been consistently on the lower side in recent years, which raises my concerns about kidney function.
A doctor once mentioned that the presence of protein in the urine indicates stage two kidney disease, while another physician advised that drinking more water before the test could elevate the values and reassured me not to worry.
However, since my values remain low, I still have some concerns.
Could this be a precursor to chronic kidney disease? Should I be monitoring anything specific or consider additional tests?
5.
Additionally, a prostate ultrasound revealed calcifications, which were also present last year.
Is this reasonable for someone in their early 30s? Is there a connection between this finding and the tests mentioned above?
Thank you.

A, 30~39 year old female. Ask Date: 2017/12/08

Dr. Du Shixi reply Urology


Hello: 1) Adjustments may vary based on age or model.
2) At 30 years old, there should theoretically be no hypertrophy issues; masturbation has little effect on PSA levels, and urinary problems should consider other factors.
3) Drink more plain water and avoid excessive salt intake.
4) Please consult a nephrologist.
5) Calcification is quite common.

Reply Date: 2017/12/08

More Info


Understanding PSA Levels and Prostate Health: Key Questions Answered
Hello! It’s great that you’re taking an active interest in your health, especially regarding your PSA levels and overall prostate health. Let’s break down your questions one by one.

1. PSA Levels and Normal Ranges: Your PSA level of 2.93 ng/ml is indeed above the normal range of 0-2.39 ng/ml as per your recent report, but it’s important to note that different laboratories may have varying reference ranges based on their testing methods and population studies. The common range of 0-4 ng/ml is often cited, but many urologists prefer a more conservative threshold, especially for younger men. An increase from 1.26 to 2.93 ng/ml in a year can be concerning, but it’s not uncommon for PSA levels to fluctuate due to various factors such as recent sexual activity, infections, or even physical activities like cycling. Lifestyle changes, such as maintaining a healthy diet, regular exercise, and managing stress, can positively influence PSA levels, but they may not necessarily bring them back to a normal range if there are underlying issues.

2. Urinary Symptoms and Prostate Health: Occasional nocturia (nighttime urination) and feelings of incomplete bladder emptying can be signs of benign prostatic hyperplasia (BPH), especially in men over 30. However, given your age, it’s less likely to be a significant issue. Frequent urination and decreased urine volume can also be influenced by hydration levels and dietary factors. Regarding masturbation, it can temporarily elevate PSA levels, so if you had engaged in this activity shortly before your blood test, it could have contributed to the elevated reading. If your urinary symptoms persist or worsen, it would be wise to consult a urologist for a thorough evaluation, which may include a digital rectal exam (DRE) despite your previous experiences.

3. Creatinine Levels: Your creatinine level of 1.34 mg/dl is slightly elevated. This could indicate that your kidneys are under some stress or not filtering waste as efficiently as they should. It’s essential to monitor this level, especially if you have risk factors for kidney disease, such as hypertension or diabetes. Staying well-hydrated, avoiding excessive protein intake, and regular check-ups can help manage your kidney health.

4. Glomerular Filtration Rate (GFR): A GFR of 66.08 ml/min is considered mildly decreased and could suggest early kidney dysfunction. While the absence of protein in your urine is a good sign, consistently low GFR readings over time should be monitored. Chronic kidney disease (CKD) is diagnosed based on GFR and the presence of other markers, such as proteinuria. If your GFR continues to decline, further evaluation and possibly a referral to a nephrologist may be warranted.

5. Prostate Calcification: The presence of calcifications in the prostate is not uncommon, especially in men in their 30s and can occur due to previous infections or inflammation. While they are generally benign, it’s essential to keep an eye on any changes in your prostate health. Regular check-ups and imaging studies can help monitor any developments.

In summary, while your PSA level and urinary symptoms may be concerning, they are not definitive indicators of prostate cancer or severe disease, especially given your age. Regular follow-ups with your healthcare provider, lifestyle modifications, and possibly further testing will be crucial in managing your health. If you have ongoing concerns, don’t hesitate to seek a second opinion or request more comprehensive evaluations. Your health is paramount, and being proactive is the best approach.

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