Pathological Examination Report of Hepatitis
Hello, Doctor.
I recently underwent a liver biopsy at the hospital.
After the examination, the physician only informed me of the presence of liver inflammation and recommended changes to my lifestyle, along with prescribing some liver-protective medications.
Unfortunately, due to the limited time during the outpatient visit, I was unable to ask more detailed questions about my hepatitis condition.
After researching online, I found that hepatitis can be classified into many different types, each with distinct symptoms and grading systems (Ishak, Knodell, METAVIR).
I would like to relay the contents of my pathology report for your review, so I can gain a better understanding of my health.
My questions are as follows: 1.
What type of hepatitis do I have? (Chronic hepatitis? Type B? Type C?) 2.
What is the current grade of my hepatitis? 3.
Is there any liver fibrosis present? 4.
Is there any steatosis? 5.
Is there any inflammatory lesion in the liver lobules? Thank you.
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Pathologic Diagnosis: Liver; biopsy: Mild steatosis and steatohepatitis (grade 1/3, stage 1/4).
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Gross Finding: The specimen consists of two fragments of gray soft tissue, measuring 2.0 cm in length.
All for section, embedded in one cassette.
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Microscopic Finding: The section shows mild steatosis (-20%).
The portal area shows mild lymphocytic infiltration.
The hepatocytes exhibit focal ballooning degeneration.
Mallory bodies are not seen.
There is no bridging fibrosis.
The special stain for copper is negative.
Steatohepatitis is favored.
Please correlate with clinical findings.
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Scoring System for Steatohepatitis:
Necroinflammatory Grading:
- Grade 1 (mild): Steatosis (mainly macrovesicular) involving up to 66% of lobules; occasional ballooned perivenular hepatocytes; scattered neutrophils with or without lymphocytes; no or mild chronic portal inflammation.
- Grade 2 (moderate): Steatosis of any degree; obvious ballooning (mainly perivenular); intralobular neutrophils, may be associated with perivenular pericellular fibrosis if evident; mild to moderate portal and intralobular chronic inflammation.
- Grade 3 (severe): Panlobular steatosis; obvious perivenular ballooning and disarray; marked lobular inflammation; neutrophils may be concentrated in perivenular areas of ballooning and in areas of pericellular fibrosis if evident.
Portal inflammation is mild or moderate.
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Fibrosis Staging:
- Stage 0-1: Minimal pericellular fibrosis in perivenular areas, focal.
- Stage 2: As above, plus focal or extensive periportal fibrosis.
- Stage 3: Bridging fibrosis, focal or extensive.
- Stage 4: Cirrhosis.
Xiao Hui, 30~39 year old female. Ask Date: 2018/01/25
Dr. Cai Anshun reply Gastroenterology and Hepatology
Hello: 1.
Mild steatosis and steatohepatitis (grade 1/3, stage 1/4).
The report indicates: it is Grade 1 fatty infiltration and Grade 1 fibrosis, both of which are classified as mild.
2.
Whether it is caused by hepatitis B or C depends on the blood test results.
Fatty liver can also lead to chronic hepatitis.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun.
Reply Date: 2018/01/25
More Info
Understanding your liver biopsy report is crucial for managing your health, especially when it comes to conditions like hepatitis. Based on the information provided in your pathology report, let's break down your questions and provide clarity on your liver condition.
1. What type of hepatitis do you have?
Your biopsy report indicates "mild steatosis and steatohepatitis." This suggests that you are experiencing a form of liver inflammation associated with fat accumulation in the liver, commonly referred to as non-alcoholic fatty liver disease (NAFLD) or steatohepatitis. While the report does not specify whether this is due to viral hepatitis (like Hepatitis B or C), the presence of steatohepatitis often indicates that other factors, such as obesity, diabetes, or alcohol consumption, may also be contributing to liver inflammation. To determine if you have viral hepatitis, additional blood tests (such as HBsAg for Hepatitis B or HCV RNA for Hepatitis C) would be necessary.
2. What is the current grade of your hepatitis?
The report states that you have a necroinflammatory grading of Grade 1 out of 3. This is classified as mild inflammation. In the context of liver disease, a Grade 1 indicates that there is some degree of inflammation and damage to liver cells, but it is not severe. This is a positive sign as it suggests that the liver is not in a critical state.
3. Is there liver fibrosis?
Your report indicates a fibrosis stage of Stage 1 out of 4. This means there is minimal fibrosis present, which is a form of scarring in the liver. Stage 1 indicates that the liver has some early signs of scarring but is still largely functioning normally. This is also a favorable finding, as significant fibrosis (Stage 2 or higher) can lead to more serious conditions, including cirrhosis.
4. Is there fatty change in the liver?
Yes, the report mentions mild steatosis, which means there is a small amount of fat accumulation in the liver (approximately 20% of the liver cells are affected). This is a common finding in individuals with metabolic syndrome, obesity, or excessive alcohol consumption. Managing your diet and lifestyle can help reduce fat accumulation in the liver.
5. Is there inflammation in the liver lobules?
The report indicates that there is mild lymphocytic infiltration in the portal areas and focal ballooning degeneration of hepatocytes, which suggests that there is indeed inflammation present in the liver. However, the absence of bridging fibrosis and the mild grading of inflammation indicate that the liver is not severely damaged at this time.
Additional Insights:
It's important to understand that liver health is multifaceted. Factors such as diet, exercise, and underlying health conditions (like diabetes or hypertension) play significant roles in liver function and overall health. Here are some recommendations:
- Lifestyle Changes: Since your report suggests mild liver inflammation and steatosis, adopting a healthier lifestyle can be beneficial. This includes maintaining a balanced diet low in saturated fats and sugars, regular physical activity, and avoiding alcohol.
- Regular Monitoring: Follow-up with your healthcare provider for regular monitoring of liver function tests and any necessary imaging studies. This will help track any changes in your liver condition over time.
- Further Testing: If there is a suspicion of viral hepatitis, it is essential to undergo the appropriate blood tests to confirm the presence of Hepatitis B or C. Early detection can lead to more effective management.
- Consultation with a Specialist: If you have concerns or if your liver function tests worsen, consider consulting a hepatologist or a gastroenterologist who specializes in liver diseases for a more comprehensive evaluation and management plan.
In conclusion, your liver biopsy results indicate mild steatosis and steatohepatitis with minimal fibrosis, which is a manageable condition. By making lifestyle changes and staying vigilant with follow-up care, you can significantly improve your liver health.
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