High Prolactin Levels: Impact on Fertility and Testing Accuracy - Obstetrics and Gynecology

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Hyperprolactinemia


I would like to ask about my blood test results showing elevated prolactin levels.
I read online that blood tests require fasting and abstinence, but I had my blood drawn twice without fasting.
Will these values be accurate? I also have polycystic ovary syndrome (PCOS) and elevated prolactin levels.
Does this really make it difficult to conceive?

Xiang Yun de Mami, 30~39 year old female. Ask Date: 2018/02/12

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, there is no need to fast for a blood test for prolactin levels.
Conditions such as polycystic ovary syndrome (PCOS) and elevated prolactin levels can both affect fertility.
It is advisable to consult a gynecologist for appropriate treatment.
Wishing you good health.

Reply Date: 2018/02/12

More Info


High prolactin levels, or hyperprolactinemia, can indeed have implications for fertility, particularly in women. Prolactin is a hormone produced by the pituitary gland, and its primary role is to promote breast milk production after childbirth. However, elevated levels of prolactin can interfere with the normal functioning of the reproductive system, potentially leading to issues such as irregular menstrual cycles, anovulation (lack of ovulation), and infertility.

Regarding your concern about the accuracy of your prolactin test results, it is important to note that certain factors can influence prolactin levels. For instance, stress, sleep, and even the act of drawing blood can temporarily elevate prolactin levels. Additionally, fasting before the test is generally recommended because food intake can also affect hormone levels. If you did not fast before your blood tests, it is possible that your prolactin levels may not accurately reflect your baseline levels. Therefore, it might be beneficial to discuss with your healthcare provider the possibility of retesting your prolactin levels under controlled conditions, such as fasting and avoiding any stressors prior to the test.

As for your condition of polycystic ovary syndrome (PCOS) combined with high prolactin levels, both can contribute to difficulties in conceiving. PCOS is characterized by hormonal imbalances that can lead to irregular ovulation or anovulation, while elevated prolactin can further disrupt the hormonal balance necessary for ovulation. Women with PCOS often experience insulin resistance, which can exacerbate hormonal imbalances, making it more challenging to conceive.

If you are trying to conceive, it is crucial to work closely with your healthcare provider to address both the high prolactin levels and the symptoms of PCOS. Treatment options for high prolactin levels may include medications such as cabergoline or bromocriptine, which can help lower prolactin levels and restore normal ovulatory function. For PCOS, lifestyle modifications such as weight management, diet, and exercise can be beneficial, and medications like metformin may also be prescribed to improve insulin sensitivity and promote ovulation.

In summary, while high prolactin levels and PCOS can pose challenges to fertility, they are not insurmountable. With appropriate medical intervention and lifestyle changes, many women with these conditions can successfully conceive. It is essential to maintain open communication with your healthcare provider, who can guide you through the necessary testing and treatment options tailored to your specific situation.

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