Your Concerns About Genital Herpes and HSV-2 Testing - Urology

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Questions about genital herpes?


Hello Dr.
Du,
In 1996, I had an instance of unprotected sexual intercourse during a business trip (the only time in my life).
After a certain number of days, I was tested for various sexually transmitted infections, all of which came back negative, including genital herpes (HSV Type 2), which had a result of 1.32.
The testing facility at that time informed me that this was normal.
Over the following years, I continued to have blood tests every one to two years, and all STI tests remained negative.
However, another lab reported my HSV 2 IgG levels to be between 1.21 and 1.34, with the report indicating a positive result (+) (with the cutoff being <0.9 (-) and >1.1 (+)).

In September of last year, I visited a different lab that used a different reagent, and my result was 29 (+) (Reference <16 (-) >22 (+)).
Since 1996, I have never experienced any symptoms of herpes, except for a few bumps on the glans in 1999 (which were not blisters, I did not apply any medication, and they almost disappeared within three to four days; a dermatologist assessed them as irritation caused by tight foreskin).
After I underwent circumcision in 1999, I have not had any episodes of balanitis and have not experienced any symptoms of herpes.
Multiple tests have consistently shown results between 1.21 and 1.34, only slightly above the threshold.
This issue has been troubling me: am I truly infected with genital herpes? I also researched on American websites, which indicated that HSV 2 IgG levels between 1.1 and 3.5 have a high chance of being false positives.
In early 2015, my wife was tested for HSV 2 IgG and had a result of 0.5 (-), and for HSV 1+2 IgM, she also had 0.5 (-).
I really don’t understand; the internet says that even without symptoms, one can still transmit the virus to others, yet for nearly 20 years, my wife has remained negative (which I am very grateful for) and has not contracted the virus from me.
But am I truly infected with genital herpes? Additionally, if I am indeed a positive HSV 2 carrier, will I transmit it to my family in my daily home life? Dr.
Du, I have so many questions that are causing me distress, and I kindly ask you to take some time to provide guidance.
Thank you very much!

Du Fen Si, 50~59 year old female. Ask Date: 2018/02/23

Dr. Du Shixi reply Urology


Hello: Herpes simplex virus can occur on any part of the body, particularly on the mouth, buttocks, genitals, and between the fingers.
The most reliable way to confirm herpes simplex is through direct viral culture or antigen testing from the lesion.
The positive culture rate for recurrent lesions decreases over time, generally within a week.
Currently, polymerase chain reaction (PCR) testing is also available.
Blood tests for antibodies typically appear 2 to 6 weeks after infection and persist for life.
Therefore, even if the test is positive, it does not indicate the presence of the herpes virus on the skin, nor can it differentiate between skin, oral, or genital infections.
It is likely that you have been infected, but due to the absence of symptoms, it is possible that the viral load is low or that the virus is not present on the skin, making transmission less likely.
Wishing you good health.

Reply Date: 2018/02/23

More Info


Understanding your concerns about genital herpes and HSV-2 testing is crucial, especially given the complexity of the situation you've described. Let's break down your concerns and provide clarity based on medical knowledge.

Firstly, it's important to understand that HSV-2 (Herpes Simplex Virus Type 2) is primarily associated with genital herpes, while HSV-1 is more commonly linked to oral herpes. However, both types can cause infections in either area. The tests you have undergone, particularly the IgG antibody tests, are designed to detect the presence of antibodies that your body produces in response to an HSV infection.
Your test results, which consistently show values between 1.21 and 1.34, indicate a positive result for HSV-2. However, the interpretation of these results can be nuanced. The reference ranges you mentioned suggest that values below 0.9 are negative, while values above 1.1 are considered positive. The range you are in (1.21 - 1.34) indicates that you have been exposed to the virus at some point, but it does not necessarily confirm an active infection or that you are currently contagious.

The concern about false positives is valid. Studies have shown that low positive results (like those in your range) can sometimes be false positives, particularly in populations with low prevalence rates of the virus. This means that while you may have antibodies present, it does not confirm that you have an active infection or that you are capable of transmitting the virus.
You mentioned that you have never experienced any symptoms associated with genital herpes, such as sores or blisters. This is significant because many individuals with HSV-2 are asymptomatic, meaning they carry the virus without ever showing symptoms. This asymptomatic nature can lead to transmission, but it is less likely if there are no active lesions or outbreaks.
Regarding your wife's negative test results, this is reassuring. It suggests that she has not been exposed to the virus, at least not in a way that has led to a detectable immune response. If you were indeed a carrier of HSV-2, it is possible to transmit the virus even without symptoms, but the risk is significantly lower when there are no active outbreaks.

As for your concerns about household transmission, HSV-2 is primarily transmitted through direct skin-to-skin contact, particularly during sexual activity. It is less likely to be transmitted through casual contact, such as sharing utensils or towels. If you maintain good hygiene and avoid intimate contact during outbreaks (if they were to occur), the risk of transmission to family members is minimal.

In summary, while your test results indicate that you have been exposed to HSV-2, the absence of symptoms over many years suggests that you may not have an active infection. The possibility of false positives exists, and your situation is not uncommon. If you remain concerned, consider discussing with a healthcare provider about the option of further testing, such as a type-specific PCR test, which can provide more definitive information about an active infection.

Lastly, managing anxiety related to health concerns is important. If your worries about HSV-2 are affecting your quality of life, consider speaking with a mental health professional who can help you navigate these feelings. Remember, many people live with HSV-2 without significant issues, and understanding the virus can help alleviate some of the fear associated with it.

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