Essential Blood Tests for Hepatitis B Carriers: A Guide - Internal Medicine

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Hepatitis B


Dear Dr.
Yang: I am a healthy carrier of hepatitis B and would like to have my liver function tested every three months.
What specific tests should I include? Besides large hospitals, where else can I get these tests done? Also, what is serum alpha-fetoprotein?

Taichung Niuniu, 20~29 year old female. Ask Date: 2000/11/27

Dr. Yang Guojun reply Internal Medicine


Please follow up every 3 to 6 months with a liver ultrasound and monitor the serum alpha-fetoprotein (AFP) levels, commonly known as the liver cancer marker, for patients in specific high-risk groups.
This long-term monitoring can be conducted at any gastroenterology and hepatology clinic.
Dr.
Yang Guojun, Gastroenterology and Hepatology Specialist, advises this approach.

Reply Date: 2000/11/27

More Info


As a hepatitis B carrier, regular monitoring of your liver health is crucial to ensure that any potential complications are detected early. The essential blood tests you should consider every three months include:
1. Liver Function Tests (LFTs): This panel typically includes measurements of enzymes such as Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (AST). Elevated levels of these enzymes can indicate liver inflammation or damage. Additionally, tests for Bilirubin levels can help assess how well your liver is functioning.

2. Hepatitis B Surface Antigen (HBsAg): This test determines whether you are currently infected with the hepatitis B virus. A positive result indicates active infection, while a negative result suggests that the virus is not currently replicating.

3. Hepatitis B Surface Antibody (Anti-HBs): This test measures the presence of antibodies against the hepatitis B virus, indicating recovery from infection or successful vaccination. A positive result suggests immunity.

4. Hepatitis B Core Antibody (Anti-HBc): This test can help differentiate between a past infection and immunity due to vaccination. A positive result indicates either a past infection or ongoing infection, while a negative result suggests no previous exposure to the virus.

5. Alpha-Fetoprotein (AFP): This is a tumor marker that can be elevated in liver cancer, particularly in individuals with chronic hepatitis B. Regular monitoring of AFP levels is important for early detection of hepatocellular carcinoma, especially in those with cirrhosis or chronic hepatitis B.

In addition to these tests, you may also want to discuss with your healthcare provider the possibility of undergoing imaging studies such as an ultrasound or elastography to assess liver stiffness, which can indicate fibrosis or cirrhosis.

As for where to get these tests done, aside from large hospitals, many community health clinics, outpatient laboratories, and specialized liver clinics offer hepatitis B testing and monitoring services. It’s important to choose a facility that has experience in managing hepatitis B, as they will be more familiar with the nuances of the disease and its management.

Regarding Alpha-Fetoprotein (AFP), it is a protein that is typically produced by the liver and yolk sac of a developing fetus. In adults, elevated levels of AFP can indicate liver diseases, including hepatitis and liver cancer. Monitoring AFP levels in hepatitis B carriers is crucial because it can serve as an early warning sign of hepatocellular carcinoma, which is a common complication of chronic hepatitis B infection.

In summary, as a hepatitis B carrier, your regular blood tests should include liver function tests, HBsAg, Anti-HBs, Anti-HBc, and AFP. Regular monitoring is essential for managing your health and preventing complications associated with hepatitis B. Always consult with your healthcare provider to tailor your monitoring plan based on your specific health needs and circumstances.

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