Chlamydia Infections: Symptoms, Diagnosis, and Treatment - Urology

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Clostridium infection


On November 15, I had sexual intercourse with a condom.
On November 25, I experienced urethral itching and tested for Chlamydia IgA, which was 0.71; the lab indicated that a result of <0.8 is considered negative.
On December 15, I had prostate pain and blood tests showed an IgA level of 1.22, which was positive.
Later, I went to the hospital for a bacterial culture, but nothing grew.
I presented the lab report to the doctor, who prescribed antibiotics.
I took them for six weeks, including Cefixime and Doxycycline, but I still feel a swelling sensation in my prostate, and it feels hard to the touch.
I also have a swelling sensation around the anal area.
I suspect that the infection hasn't cleared, but the hospital won't prescribe me more antibiotics, stating that Chlamydia is not that difficult to eradicate and that I currently have non-bacterial prostatitis.

I have been consistently getting blood tests: November 25 was 0.71, December 15 was 1.22, January 15 was 0.65, and February 15 was 0.75.
After stopping the medication, on April 15, I tested at 0.62.
Why does my IgA level keep decreasing but not below 0.8? The lab mentioned that while my result is negative, other non-infected individuals have levels below 0.2.
I am unsure if I am cured or if the bacteria are gone, and I am worried about transmitting anything to my family.
What should I do now?

Mingjun, 30~39 year old female. Ask Date: 2018/04/24

Dr. Xu Wencang reply Urology


It is not necessarily a Chlamydia infection; a urine test for Chlamydia antigens is required for accurate diagnosis.
Aseptic chronic prostatitis or pelvic pain is generally more difficult to treat and may require physical therapy or lifestyle modifications.
If there is no improvement, further consultation should be sought.

Reply Date: 2018/04/24

More Info


Chlamydia infections are a common sexually transmitted infection (STI) caused by the bacterium Chlamydia trachomatis. Understanding the symptoms, diagnosis, and treatment of chlamydia is crucial for effective management and prevention of complications.


Symptoms of Chlamydia Infections
Chlamydia infections can often be asymptomatic, meaning many individuals may not exhibit any symptoms. However, when symptoms do occur, they can include:
- Urethritis: This is characterized by symptoms such as burning during urination, increased urinary frequency, and urethral discharge.

- Pelvic Inflammatory Disease (PID): In women, untreated chlamydia can lead to PID, which may cause abdominal pain, fever, and abnormal vaginal discharge.

- Prostatitis: In men, chlamydia can lead to inflammation of the prostate gland, causing pain in the pelvic area, painful urination, and discomfort during ejaculation.

- Rectal Infections: These can occur in both men and women, leading to rectal pain, discharge, and bleeding.


Diagnosis of Chlamydia Infections
Diagnosis typically involves laboratory testing. The most common tests include:
- Nucleic Acid Amplification Tests (NAATs): These are highly sensitive and specific tests that can detect the genetic material of the bacteria in urine or swabs from the urethra, cervix, or rectum.

- Serological Tests: These tests measure antibodies (like IgA) in the blood, but they are not the primary method for diagnosing chlamydia.

In your case, the IgA levels you mentioned indicate a previous exposure or infection, but they do not definitively confirm an active infection. The fluctuation in IgA levels could be due to various factors, including the body's immune response to the infection or the treatment you received.


Treatment of Chlamydia Infections
Chlamydia is typically treated with antibiotics. Commonly prescribed antibiotics include:
- Azithromycin: A single dose is often effective.

- Doxycycline: Usually taken for a week.

- Ceftriaxone: Sometimes used in conjunction with other treatments for co-infections.

In your situation, it seems you have undergone a prolonged antibiotic treatment without significant improvement in symptoms. This could suggest that the initial diagnosis may not have been entirely accurate, or there may be another underlying issue, such as non-bacterial prostatitis or another form of infection.


Next Steps
1. Follow-Up with Healthcare Provider: Since you have persistent symptoms and concerns about your IgA levels, it is essential to follow up with your healthcare provider. They may recommend further testing, such as a repeat NAAT or additional cultures, to rule out other infections or conditions.

2. Consider Referral to a Specialist: If your primary care physician is unable to provide clarity, consider asking for a referral to a urologist or an infectious disease specialist. They can offer more targeted evaluations and treatment options.

3. Monitor Symptoms: Keep track of your symptoms, including any changes in pain, urinary habits, or other related issues. This information will be valuable for your healthcare provider.

4. Prevent Transmission: Until you have clarity on your infection status, it is wise to practice safe sex and communicate with your partner(s) about your health concerns.

5. Mental Health Support: Dealing with ongoing health issues can be stressful. Consider seeking support from mental health professionals or support groups to help manage anxiety related to your health.

In conclusion, while chlamydia infections can be effectively treated, persistent symptoms warrant further investigation. Collaborating closely with your healthcare provider will be key to resolving your concerns and ensuring your health and the health of your loved ones.

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