Anti-HIV Testing: Key Insights and Recommendations - Internal Medicine

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Anti-HIV testing issues?


Hello Dr.
Hong,
Due to certain needs, I recently went to the municipal hospital to have my blood tested for Anti-HIV after an HIV window period of 84 days.
I understand that the Anti-HIV test is an HIV antibody test, and the final test result was <0.05 (with a reference value of <1), indicating a negative result.
Upon further inquiry with the hospital's laboratory, they informed me that they use the ELISA method for testing, but it seems that it is not the latest generation.
I know that HIV is classified into two types: HIV-1 and HIV-2.
The laboratory mentioned that their HIV test kit only specifies HIV-1.

Dr.
Hong, does this mean that the hospital is only testing for HIV-1? Should I seek testing at another medical facility or laboratory that uses more advanced testing methods?
I appreciate your guidance on these questions.
Thank you for your time.

JJ, 30~39 year old female. Ask Date: 2018/04/26

Dr. Hong Yuanbin reply Internal Medicine


Hello, the ELISA test is used for initial screening for HIV.
If the result is positive, a confirmatory Western blot test is performed.
If the result is negative, regular follow-up is recommended.
Currently, the predominant strains in most countries are HIV-1 and HIV-2, with HIV-2 being limited to a few underdeveloped countries.
In Taiwan, the risk of infection is relatively low, so most screening tests available here primarily target HIV-1.
Based on your situation, it is recommended to follow up on your HIV status in approximately 3 to 6 months.
Thank you for your inquiry.

Reply Date: 2018/04/26

More Info


Hello! Thank you for your inquiry regarding Anti-HIV testing and the nuances associated with it. It’s great that you are taking proactive steps to understand your health, especially concerning HIV testing.

To begin with, the Anti-HIV test you underwent is indeed a crucial step in determining whether you have been infected with the HIV virus. The test primarily detects antibodies that your body produces in response to an HIV infection. The result you received, which is <0.05, indicates a negative result, meaning that no antibodies were detected, and you are likely not infected with HIV at this time.

Regarding the testing method, you mentioned that the hospital used an ELISA (Enzyme-Linked Immunosorbent Assay) test. This is a common and reliable method for screening HIV. However, it’s important to note that there are different generations of ELISA tests, with newer versions offering improved sensitivity and specificity. The sensitivity refers to the test's ability to correctly identify those with the virus (true positive rate), while specificity refers to correctly identifying those without the virus (true negative rate). The latest tests can detect HIV earlier in the infection process, which is crucial given the window period.

You also raised a valid point about the distinction between HIV-1 and HIV-2. HIV-1 is the most common and widespread type of HIV globally, while HIV-2 is less common and primarily found in West Africa. If the testing kit used at the hospital only specifies HIV-1, it means that the test is designed to detect antibodies specific to HIV-1. While HIV-2 is less prevalent, it is still important to consider, especially if you have risk factors or a history that might suggest exposure to this type.

Given that your test was negative and you are within the window period (84 days), it is generally considered a reliable result. However, if you have ongoing concerns or if you believe you may have been exposed to HIV-2, it would be prudent to seek further testing. You might consider visiting a facility that offers a more comprehensive testing approach, including tests that can detect both HIV-1 and HIV-2, as well as the latest generation tests that may provide quicker and more accurate results.

In addition to HIV testing, it’s also advisable to consider screening for other sexually transmitted infections (STIs), especially if you have had unprotected sex or multiple partners. Regular screening is an essential part of maintaining sexual health.

In conclusion, while your current negative result is reassuring, if you have any lingering doubts or specific concerns regarding HIV-2 or the testing methods used, seeking further testing at a facility that employs the latest technology and comprehensive testing options would be a wise choice. Always remember that early detection and treatment are key in managing any potential health issues, including HIV. Thank you for your questions, and I hope this information helps you make informed decisions about your health!

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