Trace Protein in Urine: Should You Worry? - Internal Medicine

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Both urine protein tests showed +/-?


Hello Dr.
Lin, I underwent a health check on April 18, and the report indicated trace hematuria and trace proteinuria, with increased lung markings; all other results were normal.
Today, I conducted another test, and the abnormal or borderline results are as follows:
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Urine Routine
Appearance: YELLOW
Specific Gravity: >=1.030
Protein: Trace
Urobilinogen: 1.0
Sediment
Epithelium cell: 6-9 /HPF
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Could you please advise if the presence of trace protein in both urine tests, two months apart, suggests a potential issue with my kidneys? Are there any specific precautions I should take? Thank you for taking the time to address my concerns.

Lin, 20~29 year old female. Ask Date: 2018/06/13

Dr. Lin Wuxuan reply Internal Medicine


Hello: This urine test report does indicate the presence of trace proteinuria.
Generally, if proteinuria is initially detected, it is recommended to conduct two to three follow-up tests, preferably using the first urine sample collected in the morning.
Additionally, women should avoid testing during their menstrual period to reduce interference.
Since your second follow-up test still shows trace proteinuria, it is advised to conduct another follow-up test or to visit a nephrology clinic for a quantitative urine protein analysis to accurately determine whether the amount of protein loss in the urine reaches a pathological level.
For kidney health, it is generally recommended to follow a diet low in salt, oil, and sugar, consume plenty of fresh fruits and vegetables, maintain adequate hydration, avoid foods with excessive artificial additives, and strictly control blood pressure, blood sugar, and lipid levels.

Reply Date: 2018/06/13

More Info


When it comes to trace protein in urine, it's important to understand what this finding may indicate and whether it warrants concern. The presence of trace protein in urine, particularly if it is consistently observed over multiple tests, can be a sign of underlying kidney issues, but it is not always a cause for alarm.

Firstly, let's discuss what trace protein means. In a urine test, protein levels are typically measured in milligrams per deciliter (mg/dL). A trace result indicates a very small amount of protein is present, which can be a normal finding in some individuals. The kidneys filter waste from the blood, and while they usually prevent significant amounts of protein from entering the urine, certain conditions can lead to protein leakage.

The fact that you have had trace protein in your urine on two separate occasions could suggest a few possibilities. It may be a benign condition known as "benign urinary proteinuria," which can occur due to factors such as dehydration, exercise, fever, or stress. In these cases, protein levels may normalize once the underlying cause is resolved. However, persistent trace protein could also indicate more serious conditions, such as early kidney disease, glomerulonephritis, or diabetic nephropathy, especially if you have risk factors such as diabetes or hypertension.

Given that your urine tests also showed "urine blood" (hematuria) and an increase in lung markings, it is essential to consider these findings in context. Hematuria can arise from various causes, including urinary tract infections, kidney stones, or more serious conditions like tumors. The presence of epithelial cells in your sediment analysis could indicate some irritation or inflammation in the urinary tract.

In terms of what you should do next, it is advisable to follow up with your healthcare provider for further evaluation. They may recommend additional tests, such as a 24-hour urine collection for protein quantification, kidney function tests (like serum creatinine), or imaging studies to assess the kidneys and urinary tract. These steps can help determine whether there is a significant underlying issue that needs to be addressed.

In the meantime, there are several lifestyle factors you can consider to support kidney health:
1. Stay Hydrated: Ensure you are drinking enough water throughout the day, as dehydration can concentrate urine and potentially lead to proteinuria.

2. Monitor Blood Pressure and Blood Sugar: If you have a history of hypertension or diabetes, keeping these conditions well-managed is crucial for kidney health.

3. Diet: A balanced diet low in sodium and rich in fruits, vegetables, and whole grains can support overall health and may help reduce kidney strain.

4. Avoid Over-the-Counter NSAIDs: Medications like ibuprofen can be harmful to the kidneys, especially if taken in high doses or over long periods.

5. Regular Check-ups: Keep up with regular health screenings and follow your doctor's recommendations for monitoring kidney function.

In conclusion, while trace protein in urine can be a benign finding, its persistence alongside other symptoms warrants further investigation. It is essential to work closely with your healthcare provider to determine the underlying cause and appropriate management strategies. Remember, early detection and intervention can significantly improve outcomes for kidney health.

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