To prevent the recurrence of high-altitude pulmonary edema (HAPE), it is advisable to carry the following medications: 1. Acetazolamide (Diamox) - This medication can help prevent altitude sickness and reduce the risk of HAPE. 2. Dexamethasone - A corticosteroid that may be used to reduce inflammation and prevent severe symptoms. 3. Nifedipine -
Hello Dr.
Yang, I would like to inquire about the causes and prevention of "recurrent high-altitude pulmonary edema" (HAPE).
I am a 40-year-old female and have personally experienced it twice while abroad.
The first incident occurred during an EBC trek in May 2017 at an altitude of 4,470 meters, where I developed symptoms that night, including crackling sounds in my lungs, difficulty speaking in a language I wasn't proficient in, no urination, loss of appetite, extreme fatigue, and shortness of breath even at rest.
By the next morning, I was conscious but unable to walk, and I was subsequently airlifted down for medical attention.
The second incident was in Tibet in June 2018, where I experienced altitude sickness the night before reaching Everest Base Camp (5,200 meters) while in Shigatse (3,800 meters) after having symptoms like vomiting, fever, and elevated blood pressure in Lhasa (3,680 meters).
After receiving IV fluids, my condition improved, and I continued my trek.
However, that night in Shigatse, I again noticed crackling sounds in my lungs.
The next morning, I took 5 mg of Nifedipine, which caused dizziness and instability while walking.
I started supplemental oxygen and continued to 5,200 meters, but that night my oxygen saturation dropped to 32%, and after taking another Nifedipine, I fell into a stupor.
I would like to ask Dr.
Yang: 1.
What are the causes of recurrent HAPE? 2.
Can I travel to areas above 4,000 meters again? 3.
What medications should I carry to prevent HAPE when hiking Taiwan's "100 Peaks" (I plan to go to Jiaming Lake in September)? 4.
What are the remedial measures if I develop symptoms while on the mountain? 5.
Does strengthening cardiopulmonary function help in preventing HAPE?
Ms. Li, 40~49 year old female. Ask Date: 2018/06/18
Dr. Yang Wenda reply Pulmonology
Hello: 1-2.
Each person's constitution is different; you should be cautious about your own condition and acclimatize to altitudes of 3000 to 3800 meters several times.
3.
It is recommended to visit a travel clinic to prepare relevant medications and consult a physician for usage instructions.
4.
Rest first, use supplemental oxygen, take medications, and descend quickly.
For detailed information, refer to Google "Treatment and Prevention of Altitude Sickness," published in the 27th volume, issue 6 of Family Medicine and Primary Care.
Reply Date: 2018/06/18
More Info
High Altitude Pulmonary Edema (HAPE) is a serious condition that can occur when individuals ascend to high altitudes too quickly, particularly above 2,500 meters (8,200 feet). It is characterized by fluid accumulation in the lungs, leading to symptoms such as shortness of breath, cough, fatigue, and in severe cases, confusion and loss of consciousness. Given your experiences with HAPE, it is crucial to understand the underlying causes, preventive measures, and treatment options.
1. Causes of HAPE Recurrence: The recurrence of HAPE can be attributed to several factors, including rapid ascent to high altitudes, individual susceptibility (such as a history of HAPE), and inadequate acclimatization. When you ascend too quickly, your body may not have enough time to adjust to the decreased oxygen levels, leading to increased pulmonary artery pressure and fluid leakage into the lungs. Additionally, factors such as dehydration, physical exertion, and pre-existing respiratory conditions can exacerbate the risk of developing HAPE.
2. Future High-Altitude Travel: Given your history of HAPE, it is essential to approach future high-altitude excursions with caution. While it is not impossible to travel to altitudes above 4,000 meters, it is advisable to do so only after thorough acclimatization. Gradual ascent is key—ascend no more than 300-500 meters per day after reaching 3,000 meters, and allow for rest days to help your body adjust. Consulting with a healthcare provider who specializes in high-altitude medicine before your trip is also recommended.
3. Medications for Prevention: For your upcoming hike in Taiwan, it would be prudent to carry medications that can help prevent HAPE. Acetazolamide (Diamox) is commonly used to aid acclimatization and can be taken 24 hours before ascent and continued for a few days after. Nifedipine, which you have previously used, is also effective in preventing HAPE by reducing pulmonary artery pressure. Additionally, carrying dexamethasone can be beneficial in case of acute symptoms, as it helps reduce inflammation.
4. Emergency Measures if Symptoms Occur: If you begin to experience symptoms of HAPE while on the mountain, the first step is to descend immediately to a lower altitude. Supplemental oxygen can also be administered if available. Rest is crucial, and if symptoms persist or worsen, seek medical attention as soon as possible. Avoid any further ascent until you have fully recovered.
5. Strengthening Cardiopulmonary Function: Improving your overall cardiovascular and pulmonary health can indeed help mitigate the risk of HAPE. Engaging in regular aerobic exercise, such as running, cycling, or swimming, can enhance your cardiovascular fitness. Additionally, practicing breathing exercises and spending time at moderate altitudes before your trip can help your body adapt better to high-altitude conditions.
In summary, while your history of HAPE poses challenges for future high-altitude activities, careful planning, gradual ascent, and appropriate medication can significantly reduce your risk. Always prioritize acclimatization and listen to your body’s signals. If you experience any concerning symptoms, do not hesitate to descend and seek help. Safe travels and enjoy your hiking adventures!
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