Vaccination Guidance for Infants: Navigating Delays and Combination Shots - Pediatrics

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Children receiving vaccinations?


Hello Dr.
Hsiao! I would like to ask you about my daughter, who was born on April 30th this year and is now over 2 months old.
She is due for her first dose of the pentavalent vaccine, but since we are currently in Shanghai and there is a shortage of the pentavalent vaccine here, we followed the local doctor's advice and administered a single dose of inactivated poliovirus vaccine (IPV).
If we return to Taiwan in mid-August to receive the first dose of the pentavalent vaccine, will this cause any issues with the poliovirus component being repeated in her body? Is this an acceptable approach? At that time, can she also receive the 13-valent pneumococcal conjugate vaccine and the oral rotavirus vaccine? Additionally, since she will be over 3 months old when she receives her first dose of the pentavalent vaccine, is this considered too late, and could it have any negative effects? When should the second dose of the pentavalent vaccine be administered? Thank you!

Ms. Su, 40~49 year old female. Ask Date: 2018/07/24

Dr. Xiao Kaiwen reply Pediatrics


There will be no impact.
Generally, it is less common to administer them this way.
At that time, it is possible to receive the 13-valent pneumococcal vaccine and the oral rotavirus vaccine simultaneously.
The only risk of delaying the vaccination is the lack of protection, which increases the risk of contracting the disease.
The second dose can be given as early as one and a half months after the first dose.

Reply Date: 2018/07/24

More Info


Vaccination is a crucial aspect of pediatric healthcare, and it’s understandable to have concerns about timing and the types of vaccines your child receives, especially when living abroad. In your case, your daughter was born on April 30 and is currently over two months old. You mentioned that due to a shortage in Shanghai, she received a single dose of the inactivated polio vaccine (IPV) instead of the combination DTaP-Hib-IPV-HepB (5-in-1) vaccine.
First, let’s address your concern about the potential overlap of the IPV vaccine. The IPV vaccine is safe to administer multiple times, and receiving it again as part of the 5-in-1 vaccine will not harm your child. In fact, it is common practice to administer IPV separately before combining it with other vaccines. The immune system is capable of handling multiple doses of the same vaccine, as it helps to build a stronger immunity against the disease.

When you return to Taiwan in mid-August, it is advisable to proceed with the 5-in-1 vaccine as planned. The Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) recommend that children receive their vaccinations on schedule, but they also recognize that delays can occur. If your daughter receives the 5-in-1 vaccine at that time, it will still be effective, even if she is slightly older than the typical vaccination schedule.
Regarding your question about administering the 13-valent pneumococcal conjugate vaccine (PCV13) and the oral rotavirus vaccine at the same time, this is generally acceptable. Many healthcare providers follow the guidelines that allow for the simultaneous administration of multiple vaccines, as long as they are given in different injection sites (if applicable) and are not contraindicated. This approach helps ensure that children receive the necessary immunizations without unnecessary delays.

As for your concern about starting the 5-in-1 vaccine at three months, while it is ideal to stick to the recommended vaccination schedule, starting vaccinations later is still beneficial. The key is to ensure that your child receives all the necessary doses within the recommended timeframe. The 5-in-1 vaccine is typically administered in a series of three doses, with the first dose given at two months, the second dose at four months, and the third dose at six months. If your daughter receives her first dose at three months, you can still follow up with the second dose at four months and the third dose at six months, maintaining the recommended intervals as closely as possible.

In summary, it is safe for your daughter to receive the IPV vaccine again as part of the 5-in-1 vaccine, and you can administer the PCV13 and rotavirus vaccines concurrently. Starting the 5-in-1 vaccine at three months is not ideal but still acceptable, and you should aim to keep the subsequent doses on schedule. Always consult with your healthcare provider for personalized advice and to ensure your child’s vaccination records are up to date. Vaccination is a vital step in protecting your child from serious diseases, and staying informed will help you navigate any challenges that arise.

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