Impact of Progesterone Schedule on Menstrual Cycle Timing - Obstetrics and Gynecology

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The impact of progesterone administration schedule?


Hello Doctor, I started my menstrual period and visited the obstetrics and gynecology department on July 13.
That evening, I began taking the first pack of medication (progesterone + estrogen) prescribed by the clinic, which was for a duration of 7 days, at a dosage of two packs per day, continuing until July 20.
My period is expected to arrive three days later, on July 23.
I consistently took the medication from July 13 to 18, and I started experiencing premenstrual symptoms such as water retention and constipation.
However, after July 19, I forgot to take the medication due to work and ended up taking only one pack per day, finishing the medication on July 20.

Could you please let me know if this will affect the timing of my menstrual period? Generally, how long after stopping the medication should I wait before seeing a gynecologist if my period does not arrive? Thank you, Doctor! I am currently suffering from water retention and feeling helpless.

Lana, 20~29 year old female. Ask Date: 2018/07/25

Dr. Huang Jianzhong reply Obstetrics and Gynecology


Due to my menstrual period, I visited a gynecologist on July 13th.
That evening, I started taking the first pack of medication (progesterone + estrogen) prescribed by the clinic, which was a 7-day supply, taking two packs a day until July 20th.
My period was expected to arrive three days later, on July 23rd.
I consistently took the medication from July 13th to 18th, and I began to experience symptoms such as water retention and constipation.
However, after July 19th, I forgot to take the medication due to work and ended up taking only one pack a day, finishing the medication on July 20th.
My question is, will this affect the timing of my menstrual period?
Answer: Yes, it can affect the timing of your menstrual period.
Generally, how long after stopping the medication should I wait before seeing a gynecologist if my period does not arrive?
Answer: 14 days.

Reply Date: 2018/07/25

More Info


The impact of progesterone and estrogen on the menstrual cycle is a nuanced topic that involves understanding the hormonal interplay and how medication schedules can influence menstrual timing. In your case, you started taking a combination of progesterone and estrogen on July 13 and followed the prescribed regimen for seven days. You mentioned experiencing premenstrual symptoms such as water retention and constipation, which are common side effects of hormonal treatments.

To address your question about whether the inconsistency in your medication schedule could affect your menstrual cycle timing, it is important to note that hormonal medications can indeed influence the timing of menstruation. When taken consistently, progesterone and estrogen can help regulate the menstrual cycle, often delaying or advancing the onset of menstruation depending on the timing of administration.
In your situation, since you took the medication as prescribed for the first six days but then missed doses on July 19 and 20, this inconsistency could potentially alter the expected timing of your menstrual period. Hormonal fluctuations caused by missed doses may lead to a delay in menstruation, as the body may not receive the consistent hormonal signals it requires to trigger the menstrual cycle.
Typically, after stopping hormone therapy, menstruation can resume within a few days to a few weeks, but this can vary significantly from person to person. If your period does not arrive within a week after you expected it (in your case, by July 23), it would be advisable to consult your gynecologist. They can assess your situation more thoroughly and determine if further evaluation or intervention is necessary.

In summary, the inconsistency in your medication schedule could potentially affect the timing of your menstrual cycle. If your period does not arrive as expected, it is best to seek medical advice. Additionally, if you continue to experience significant side effects such as water retention, it is important to discuss these with your healthcare provider, as they may need to adjust your treatment plan or provide additional support to alleviate these symptoms. Remember, maintaining open communication with your healthcare provider is key to managing your menstrual health effectively.

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