Epididymis Issues: What to Know About Size Differences - Urology

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Epididymal issues


Hello doctor, I have noticed that the end of my left epididymis is noticeably larger than the right side.
It feels like a round mass, and it is not painful at the moment.
Is this normal? (I had a urinary tract infection a few months ago and was treated with antibiotics.)

Lurén, 10~19 year old female. Ask Date: 2018/08/17

Dr. Du Shixi reply Urology


Hello: If there is no tenderness and it does not increase in size, there is no concern.
It is recommended to monitor the situation.
Wishing you good health.

Reply Date: 2018/08/17

More Info


When it comes to the size differences in the epididymis, it is important to understand the anatomy and function of this structure. The epididymis is a coiled tube located at the back of each testicle, responsible for storing and maturing sperm. It is not uncommon for individuals to notice asymmetry in the size of their epididymis, which can be attributed to various factors.

In your case, you mentioned that the left epididymis appears larger than the right and feels like a round mass. While some degree of asymmetry can be normal, especially if there is no associated pain or discomfort, it is essential to consider a few key points:
1. Normal Variations: It is not unusual for one side of the epididymis to be slightly larger than the other. This can be due to natural anatomical variations. However, significant changes in size or the presence of a palpable mass should be evaluated further.

2. Post-Infection Changes: Since you mentioned a history of urethral infection treated with antibiotics, it is possible that the infection could have caused some inflammation or swelling in the epididymis, leading to a temporary increase in size. Epididymitis, which is inflammation of the epididymis, can result from infections and may cause swelling, tenderness, and sometimes a palpable mass.

3. Potential Concerns: While many cases of epididymal enlargement are benign, it is crucial to rule out other conditions. These can include:
- Epididymal Cysts: These are fluid-filled sacs that can develop in the epididymis and are usually harmless.

- Spermatocele: A type of cyst that contains sperm and can also present as a lump.

- Varicocele: Enlarged veins within the scrotum that can sometimes be mistaken for epididymal enlargement.

- Tumors: Although rare, tumors can develop in the epididymis or testicle, and any new or unusual mass should be evaluated.

4. When to Seek Medical Attention: If the size difference persists, increases, or is accompanied by symptoms such as pain, swelling, fever, or changes in urination, it is advisable to consult a healthcare professional. A physical examination, along with imaging studies such as an ultrasound, may be necessary to assess the situation further.

5. Follow-Up: Given your history of urinary tract infection, it might be beneficial to have a follow-up appointment with your healthcare provider. They can perform a thorough examination and determine if any additional tests are needed to ensure that there are no underlying issues.

In summary, while a slight size difference in the epididymis can be normal, especially after an infection, it is essential to monitor the situation. If you notice any changes or have concerns, do not hesitate to seek medical advice. Early evaluation can help rule out any serious conditions and provide peace of mind.

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