Slow Recovery in Acute Miliary Tuberculosis Treatment - Pulmonology

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After taking medication for tuberculosis for almost a year, the X-ray shows that the area of the white shadow in the lungs has only decreased slightly?


Hello Dr.
Yang,
I was diagnosed with acute miliary tuberculosis in September of last year.
However, due to an allergy to medications, my doctor prescribed only INH and RMP.
I had negative sputum tests until June of this year, but during a follow-up visit at the university hospital in April, the doctor informed me that there were still significant opacities on my X-ray.
My recovery has been slower than expected, so he prescribed medication for me to continue until September, when I will return for another X-ray.

Dr.
Yang, is this situation normal? Do I need to continue taking the medication for a few more months to fully recover? I am concerned that I might have developed drug-resistant tuberculosis, which could be causing my slow recovery.
Thank you, Dr.
Yang.

Nìmíng, 20~29 year old female. Ask Date: 2018/08/20

Dr. Yang Wenda reply Pulmonology


Hello: A recommended treatment duration of one year (364 days) is appropriate, unless there is still fever or the X-ray findings have worsened compared to before, in which case a reevaluation is necessary!

Reply Date: 2018/08/20

More Info


Acute miliary tuberculosis is a severe form of tuberculosis (TB) that can spread throughout the body, often leading to a variety of complications. Your situation, where you were diagnosed in September and have been experiencing slow recovery, is understandably concerning. Let’s break down your concerns regarding the slow recovery, the need for prolonged treatment, and the potential for drug-resistant TB.

First, it is important to understand that recovery from acute miliary tuberculosis can be a slow process, especially if the disease was extensive at the time of diagnosis. The presence of "white shadows" on your X-ray indicates that there are still areas of inflammation or infection in your lungs. This is not uncommon, even in patients who have been on appropriate treatment. The fact that your sputum tests have been negative for TB bacteria is a positive sign, suggesting that the active infection may be under control, but it does not necessarily mean that all the lung damage has healed.

The duration of treatment for tuberculosis typically ranges from 6 to 12 months, depending on the severity of the disease and the patient's response to therapy. In your case, since you have experienced an allergic reaction to some medications, your healthcare provider may have had to adjust your treatment regimen, which can also affect recovery time. It is crucial to adhere to the treatment plan prescribed by your physician and to attend follow-up appointments for monitoring.

Regarding your concern about drug-resistant TB, it is a valid worry, especially if you have been on a limited regimen due to allergies. Drug resistance can occur if the bacteria are exposed to insufficiently effective treatment, which can happen if the treatment is not fully effective or if the patient does not adhere to the prescribed regimen. However, the presence of negative sputum tests is reassuring, as it suggests that the active bacterial load is low or absent.

Your doctor’s recommendation to continue treatment until September and to monitor your progress with follow-up X-rays is appropriate. It is essential to give your body time to heal, as the recovery from miliary TB can take longer than expected. The presence of residual shadows on X-ray does not necessarily indicate ongoing active disease but may reflect previous inflammation or scarring.

In summary, your situation is not uncommon, and it is normal for recovery from acute miliary tuberculosis to take time. Continuing your treatment as prescribed, attending follow-up appointments, and maintaining open communication with your healthcare provider are crucial steps in your recovery process. If you have concerns about the effectiveness of your treatment or the possibility of drug resistance, do not hesitate to discuss these with your doctor. They may consider additional tests, such as drug susceptibility testing, to ensure that your treatment plan is optimal for your situation. Remember, patience and adherence to treatment are key components in overcoming tuberculosis.

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