Can Medication Affect Herpes Blood Test Results? A Urology Inquiry - Urology

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May I ask the doctor?


I have symptoms in my genital area.
I was diagnosed with genital herpes at the dermatology department.
The doctor prescribed me an antiviral ointment, Antiviral Cream, which I applied twice on the same day.
I did not take any oral medication.
The next day, I went to a hospital in Taipei, where the doctor prescribed me medication for balanitis: 1.
Alkantin 100 mg (I informed him that I had just recovered from gastroesophageal reflux about a week ago) and 2.
Broen-C3.Xyzune 5 mg.
I received these three medications, as well as an external ointment, Lindelung Ointment.
After receiving the medication, I took the oral medications immediately (I have not applied the Lindelung Ointment yet).
An hour later, I went to a nearby laboratory to have blood drawn for testing for herpes simplex virus types 1 and 2.
The test results came back normal.
I would like to ask if it is possible that the results were affected because I had already applied the ointment and taken the medication, which was less than a day ago? Thank you.

CH, 30~39 year old female. Ask Date: 2018/08/23

Dr. Du Shixi reply Urology


Hello: Using topical medications or taking oral medications will not affect test results.
Wishing you good health.

Reply Date: 2018/08/23

More Info


When it comes to the impact of medications on herpes blood test results, it's important to understand how these tests work and the potential effects of various treatments. Herpes Simplex Virus (HSV) testing typically involves serological tests that detect antibodies to the virus, specifically IgG and IgM antibodies. These antibodies are produced by the immune system in response to an infection, and their presence indicates whether a person has been exposed to the virus.

In your case, you mentioned using topical antiviral medication (Antiviral cream) and taking oral medications shortly before your blood test. Generally, topical antiviral treatments like the one you used do not affect the results of serological tests for herpes. This is because these tests measure the body's immune response (antibody production) rather than the virus itself. The antibodies can take time to develop after an initial infection, typically several weeks to months, which means that if you were recently infected, the test might not detect the antibodies yet, leading to a false-negative result.

Oral medications, such as those prescribed for other conditions, typically do not interfere with herpes testing either. However, if you were in the early stages of an infection, it is possible that your body had not yet produced enough antibodies to be detected by the test. This is known as the "window period," which is the time between exposure to the virus and the development of detectable antibodies.

In your situation, since you had symptoms of genital herpes and received treatment shortly before the blood test, it is crucial to consider the timing of your symptoms in relation to the test. If your symptoms developed recently, and you were tested shortly thereafter, it is plausible that the antibodies had not yet formed, resulting in a negative test despite the presence of the virus.

Moreover, the medications you mentioned, such as Alkantin and Broen-C3, are not known to interfere with herpes testing. They are typically used for other medical conditions and do not have a direct impact on the immune response related to HSV.

In summary, while medications, particularly topical antivirals, do not typically affect herpes blood test results, the timing of the test in relation to your symptoms is critical. If you suspect that you may have been recently infected, it may be advisable to retest after a few weeks to ensure accurate results. Additionally, discussing your concerns with your healthcare provider can provide further clarity and guidance tailored to your specific situation. They may recommend follow-up testing or alternative diagnostic methods, such as a PCR test, which can detect the virus directly and may be more appropriate if you are experiencing active symptoms.

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