Post-Exposure Prophylaxis: Risks and Testing for STIs - Urology

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Post-exposure prophylaxis (PEP)


Hello, I engaged in unprotected oral sex at the end of October 2017, where I was the one performing oral sex, and the other party did not ejaculate in my mouth.
I did not notice any unusual symptoms in my mouth.
Additionally, we also engaged in mutual masturbation.
Within 48 hours after this sexual encounter, I went to the hospital for post-exposure prophylaxis.
After completing the medication one month later, I was tested for syphilis and HIV, both of which were negative.
Three months later, I had a follow-up blood test, which also returned negative results.
Since then, I have not engaged in any sexual activity with anyone.
Recently, I was diagnosed with genital warts, which led me to think it might be related to that sexual encounter last October.
I suddenly became concerned about the possibility of other sexually transmitted infections.
I would like to know if I need to get retested.
Is it safe to assume that I am clear of infections since my test results were negative three months after that encounter? I look forward to your prompt response, and I greatly appreciate it!

Miruko, 20~29 year old female. Ask Date: 2018/09/30

Dr. Du Shixi reply Urology


Hello: If you have been tested at the hospital after one hundred days, the chance of infection is extremely low.
However, if there have been any other unsafe sexual practices, it is advisable to retest.
Wishing you good health.

Reply Date: 2018/09/30

More Info


Hello! Thank you for reaching out with your concerns regarding your sexual health and the potential risks associated with your past sexual encounter. It’s important to address these issues comprehensively, especially considering your history of exposure and subsequent health concerns.

First, let’s clarify the situation regarding your exposure and the testing you have undergone. You mentioned that you engaged in oral sex and mutual masturbation, and you received post-exposure prophylaxis (PEP) within 48 hours, which is a critical step in reducing the risk of HIV transmission. Following the completion of your PEP regimen, you tested negative for both syphilis and HIV at one month and again at three months. These results are reassuring, as they indicate that you did not contract HIV or syphilis from that encounter.

However, it’s essential to understand that while you have tested negative for HIV and syphilis, there are other sexually transmitted infections (STIs) that could potentially be transmitted through oral sex and mutual masturbation. For instance, infections such as gonorrhea, chlamydia, and herpes can also be transmitted through oral-genital contact. Additionally, human papillomavirus (HPV), which you mentioned in relation to your recent diagnosis of genital warts (often referred to as "cauliflower" due to its appearance), is another STI that can be transmitted through skin-to-skin contact during sexual activity.

Regarding your concern about whether you should get retested: since you have already tested negative for HIV and syphilis after three months, you can be reasonably assured that you did not contract these infections from the encounter in question. However, if you are experiencing new symptoms or have concerns about other STIs, it is advisable to consult with a healthcare provider about getting tested for other STIs, including gonorrhea, chlamydia, and HPV. Testing for these infections can provide peace of mind and ensure that any potential issues are addressed promptly.

It’s also worth noting that HPV is quite common, and many sexually active individuals will be exposed to it at some point in their lives. While most HPV infections resolve on their own, some strains can lead to genital warts or increase the risk of certain cancers. If you have been diagnosed with genital warts, it’s important to discuss treatment options with your healthcare provider. They can provide guidance on managing the condition and reducing the risk of transmission to partners.

In summary, while your negative test results for HIV and syphilis are encouraging, it would be prudent to discuss with your healthcare provider the possibility of testing for other STIs, especially given your recent diagnosis of genital warts. Regular STI screenings are an important part of sexual health, particularly if you have new partners or engage in activities that may increase your risk. Remember, open communication with your healthcare provider is key to maintaining your sexual health and addressing any concerns you may have. Thank you for your question, and I hope this information helps you feel more informed and empowered regarding your health!

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