Can Hormone Replacement Therapy Affect Blood Pressure Levels? - Cardiology

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Blood pressure issues?


Hello Doctor,
Two years ago, I went to the emergency room due to acute hypertension (my systolic blood pressure spiked to 208) and was subsequently diagnosed with hypertension.
I have been taking antihypertensive medication for two years, and recently my blood pressure has significantly decreased.
My cardiologist said I no longer have hypertension, and I have not taken medication for the past two days; my blood pressure is currently around 104/74.

Over two years ago, due to menopausal discomfort, my gynecologist strongly recommended hormone replacement therapy (Estradiol 1 mg and Norethisterone Acetate 0.5 mg).
I was on this hormone therapy for 2.5 years and stopped three months ago, after which my blood pressure began to lower to normal levels.
I found some information online indicating that certain medications can cause elevated blood pressure.

Could you please advise if the hormone replacement therapy I was taking could have contributed to elevated blood pressure? (My gynecologist never mentioned this risk.) Thank you very much for your response!

Ms. Zhang, 50~59 year old female. Ask Date: 2018/10/05

Dr. He Dongjin reply Cardiology


Hello, hormones can raise blood pressure? It should not be the case that hormonal instability affects blood pressure stability.
Currently, it is recommended to just monitor the situation without the need for medication.
Changhua Hospital cares about you.

Reply Date: 2018/10/05

More Info


Hormone Replacement Therapy (HRT) can indeed have an impact on blood pressure levels, and your experience highlights an important aspect of managing both hypertension and menopausal symptoms. HRT, particularly estrogen and progestin combinations, is commonly prescribed to alleviate symptoms associated with menopause, such as hot flashes, mood swings, and vaginal dryness. However, the effects of HRT on blood pressure can vary depending on individual health factors, the specific hormones used, and the duration of therapy.

Estrogen has been shown to have a complex relationship with blood pressure. In some studies, estrogen may have a protective effect on the cardiovascular system, potentially leading to lower blood pressure levels. However, in other cases, particularly in women who have other risk factors for cardiovascular disease, estrogen can lead to increased blood pressure. This is particularly true if there is a history of hypertension or if the individual is predisposed to developing high blood pressure.

Progestins, on the other hand, can have varying effects on blood pressure. Some forms of progestin may cause fluid retention, which can lead to an increase in blood pressure. This is particularly relevant for women who are already experiencing hypertension or who have a history of high blood pressure. The specific type of progestin used in HRT can influence this effect, with some being more likely to cause increases in blood pressure than others.

In your case, it seems that after discontinuing HRT, your blood pressure began to normalize. This could suggest that the hormones you were taking may have contributed to your elevated blood pressure levels. It is also worth noting that the body can undergo significant changes during and after menopause, which can affect blood pressure independently of HRT. The reduction in blood pressure you are experiencing could be a natural response to hormonal changes as well.

It is essential to monitor your blood pressure regularly, especially after making changes to your medication regimen. If your blood pressure remains stable and within a normal range, it may indicate that discontinuing HRT was beneficial for your cardiovascular health. However, if you experience any symptoms such as dizziness, fatigue, or other concerning signs, it is crucial to consult with your healthcare provider.

In conclusion, while HRT can be beneficial for managing menopausal symptoms, it is important to consider its potential effects on blood pressure. Each individual's response to HRT can vary, and it is essential to have open discussions with your healthcare provider about the risks and benefits of hormone therapy, especially if you have a history of hypertension. Regular monitoring and adjustments to your treatment plan can help ensure that both your menopausal symptoms and blood pressure are managed effectively.

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