Consultation on Hair Loss Medications: Options and Recommendations - Dermatology

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Consultation for Hair Loss Medications


Hello, doctor.
I have a family history of male pattern baldness and I am currently 31 years old.
I have been taking 1/4 of a Finasteride tablet daily for a year, and I have noticed a significant amount of new hair growth, but I am still not very satisfied.
I am considering switching to "Dutasteride" capsules (Avodart).
Is this suitable for me, and is the dosage one capsule per day? Or do you have other medication recommendations? I currently take my medications before bedtime; will this timing affect the liver's metabolism and reduce the efficacy of the medication?

Dà Huáng, 30~39 year old female. Ask Date: 2018/10/29

Dr. Wu Yuxin reply Dermatology


I'm sorry, but without seeing the patient, I cannot provide any recommendations.

Reply Date: 2018/10/29

More Info


When it comes to hair loss, particularly androgenetic alopecia (commonly known as male pattern baldness), there are several treatment options available, including medications, topical solutions, and lifestyle changes. Given your family history of hair loss and your current treatment regimen, it's important to consider both the effectiveness and safety of any new medications you might be contemplating.


Current Treatment: Finasteride
You mentioned that you have been taking Finasteride (often marketed as Propecia) at a reduced dose (1/4 of a tablet daily) for a year, and you have noticed some new hair growth. Finasteride works by inhibiting the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), the hormone primarily responsible for hair loss in genetically predisposed individuals. While many patients experience positive results, the degree of effectiveness can vary, and some may not achieve the desired fullness of hair.


Considering Dutasteride (Avodart)
You are considering switching to Dutasteride (Avodart), which is another 5-alpha-reductase inhibitor. Dutasteride inhibits both type I and type II 5-alpha-reductase, potentially making it more effective than Finasteride for some individuals. The standard dosage for Dutasteride is typically one capsule (0.5 mg) taken once daily. However, it is crucial to consult with your healthcare provider before making any changes to your medication regimen. They can provide personalized advice based on your medical history and current health status.


Timing and Administration
You mentioned taking your medications at bedtime. While the timing of medication can sometimes influence absorption and effectiveness, both Finasteride and Dutasteride can be taken at any time of day, with or without food. The liver metabolizes these medications, but taking them at night should not significantly impact their effectiveness. However, consistency in timing is key to maintaining stable drug levels in your system.


Other Treatment Options
In addition to medications, there are other treatment modalities you might consider:
1. Minoxidil (Rogaine): This topical solution can be used in conjunction with oral medications. It works by increasing blood flow to hair follicles and can promote hair growth. It is available over-the-counter and does not require a prescription.

2. Hair Transplant Surgery: For those who have significant hair loss, surgical options like hair transplants can provide a more permanent solution. This involves relocating hair follicles from areas of the scalp with dense hair to balding areas.

3. Low-Level Laser Therapy (LLLT): This non-invasive treatment uses laser light to stimulate hair follicles and promote hair growth. It can be used in conjunction with other treatments.

4. Lifestyle Changes: Maintaining a balanced diet rich in vitamins and minerals, managing stress, and avoiding smoking can also support hair health. Stress management techniques, such as mindfulness or therapy, can be beneficial, especially if stress is a contributing factor to your hair loss.


Consultation with a Specialist
Before making any changes to your treatment plan, it is advisable to consult with a dermatologist or a healthcare provider specializing in hair loss. They can assess your current treatment's effectiveness, discuss potential side effects, and help you weigh the benefits and risks of switching to Dutasteride or adding other treatments. Additionally, they can monitor your progress and make adjustments as needed.

In conclusion, while Finasteride has shown some effectiveness for you, considering Dutasteride may be a viable option, but it should be done under medical supervision. Combining treatments, maintaining a healthy lifestyle, and seeking professional guidance will provide the best chance for managing hair loss effectively.

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