Managing Benign Prostatic Hyperplasia: Key Questions and Concerns - Urology

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Benign Prostatic Hyperplasia (BPH)


Hello, Doctor.
I have issues with benign prostatic hyperplasia and chronic prostatitis.
I am currently taking Harnalidge OCAS (0.4 mg) extended-release film-coated tablets, and I have been on this medication for over three months.
My urination has been normal.
I would like to ask: 1.
Is it possible to stop the medication and only take it when I experience difficulty urinating? 2.
Does long-term use of this medication have any side effects that could harm the liver or kidneys? 3.
Will stopping the medication and then resuming it lead to drug resistance? 4.
Does having urinary issues due to benign prostatic hyperplasia mean that I will need to take medication for life? Thank you, Doctor.

LKK, 60~69 year old female. Ask Date: 2018/11/03

Dr. Du Shixi reply Urology


Hello: 1) It is not recommended to stop.
2) No, unless there are pre-existing liver or kidney issues that are not caused by the medication.
3) Some patients who stop the medication and then resume it when symptoms reappear may find that the effects are not as good as when they were using it previously.
4) For chronic conditions, long-term use is advised.
Wishing you good health.

Reply Date: 2018/11/03

More Info


Managing benign prostatic hyperplasia (BPH) can be a complex issue, especially when considering the various treatment options and the potential side effects of medications. Based on your situation, where you have been taking Harnalidge OCAS (tamsulosin) for over three months and are experiencing normal urination, let's address your questions one by one.

1. Can I stop the medication and resume it only when I have urinary difficulties?
It is generally not advisable to stop medication for BPH without consulting your healthcare provider. Tamsulosin is an alpha-blocker that helps relax the muscles in the prostate and bladder neck, making it easier to urinate. If you stop taking it, you may experience a return of symptoms, and it might take time for the medication to become effective again if you resume it later. It's best to discuss your current symptoms and the possibility of adjusting your medication regimen with your doctor.

2. Does long-term use of this medication cause liver or kidney damage?
Tamsulosin is generally considered safe for long-term use, but like any medication, it can have side effects. While liver and kidney damage are not common side effects, it is essential to monitor liver and kidney function periodically, especially if you have pre-existing conditions. Your healthcare provider should evaluate your overall health and any potential risks before making recommendations about long-term use.

3. Will stopping the medication and then resuming it lead to drug resistance?
Tamsulosin does not typically lead to drug resistance in the way that antibiotics might. However, if you stop taking it and your symptoms return, you may find that it takes longer for the medication to work effectively again. This is not due to resistance but rather the time it takes for your body to respond to the medication after a break. Always consult your doctor before making changes to your medication regimen.

4. Does having BPH and urinary difficulties mean I will need to take medication for life?
BPH is a chronic condition, and while many men manage it successfully with medication, some may require surgical intervention if symptoms become severe or unmanageable. The need for lifelong medication varies from person to person. Some individuals may find that lifestyle changes, such as diet and exercise, can help manage symptoms, while others may need ongoing medication. Regular follow-ups with your healthcare provider are crucial to assess your condition and adjust treatment as necessary.

In addition to these points, it's important to consider lifestyle modifications that can help manage BPH symptoms. These may include:
- Dietary Changes: Reducing caffeine and alcohol intake can help minimize urinary frequency and urgency.

- Fluid Management: Limiting fluid intake in the evening can help reduce nighttime urination (nocturia).

- Regular Exercise: Maintaining a healthy weight and staying active can improve overall prostate health.

- Pelvic Floor Exercises: Kegel exercises can strengthen the pelvic floor muscles and improve urinary control.

In conclusion, managing BPH is a collaborative process between you and your healthcare provider. Regular check-ups, open communication about your symptoms, and a comprehensive approach to treatment will help you maintain a good quality of life. If you have any concerns about your medication or symptoms, do not hesitate to reach out to your doctor for personalized advice and support.

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