Deep Neck Infections, Lymphadenopathy, and Mumps - Otolaryngology

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Is it a deep neck infection, lymphadenopathy, or mumps?


Hello, doctor.
Recently, I experienced tightness on the left side of my neck, which I initially thought was due to a stiff neck.
However, after two or three days, my left neck became swollen, with the most painful area located just below the earlobe, extending towards the middle of my neck.
Essentially, the entire left side of my neck, including the lateral and posterior areas, felt red, swollen, hot, and painful.
Therefore, I sought medical attention.
My cheek was not affected, nor was the front of my neck or my jaw.
The first doctor I consulted told me it was a deep neck infection and warned that if not treated properly, it could lead to sepsis, which made me very anxious.
When I asked for the cause, the doctor explained that there are many bacteria in the air, and then prescribed me antibiotics (amoxicillin-clavulanate) and steroids.
Since I had never heard of such a condition, I researched online and found many alarming things, so I sought a second opinion.
After informing the second doctor of the first doctor's diagnosis, he suggested that it was likely lymphadenopathy and mentioned that the treatment for both diagnoses was essentially the same, so he prescribed the same medication.
A week later, although there was still some swelling and pain, the follow-up doctor advised me to just observe and did not prescribe any medication.
However, two days after stopping the medication, the swelling returned.
Upon returning for another follow-up, the doctor prescribed amoxicillin again, but I felt something was off, so I sought a third opinion.
This doctor believed it was mumps and prescribed cefixime.
I would like to ask: 1.
Are these three conditions very similar? I don't understand why there are three different diagnoses.
2.
Is the swelling due to insufficient treatment with antibiotics for a week, or is it because the medication was ineffective? 3.
Should I take amoxicillin or cefixime? Or are these two essentially the same? 4.
Should I ask the doctor to conduct further tests to determine the cause, or is it sufficient to just take the medication? I apologize for not being a professional, but I hope to help the doctor grasp the key points quickly during the short consultation time, so I have many questions.
Thank you for taking the time to respond.

Chen, 30~39 year old female. Ask Date: 2018/11/10

Dr. Ji Zhaoyun reply Otolaryngology


Hello, based on your description, it is possible that you are experiencing parotitis accompanied by cervical lymphadenopathy.
If the condition continues to progress, it may lead to a deep neck infection, which is typically treated with medication, and antibiotics will be necessary if the lymphadenopathy worsens and results in a deep neck infection.
These three conditions are interrelated but vary in severity.
If the condition is still progressing, it is advisable to consult an otolaryngologist and take medication as needed.
Wishing you safety and good health.
Sincerely, Chi Chao-Yun, Taichung Hospital, Ministry of Health and Welfare.

Reply Date: 2018/11/10

More Info


Understanding the distinctions between deep neck infections, lymphadenopathy, and mumps is crucial for proper diagnosis and treatment. Each of these conditions can present with similar symptoms, such as swelling and pain in the neck, but they have different underlying causes and implications.

1. Similarities and Differences:
- Deep Neck Infections: These are serious infections that can involve the spaces in the neck and can lead to complications such as abscess formation or even sepsis if not treated promptly. Symptoms often include severe pain, swelling, fever, and difficulty swallowing or breathing. The pain is usually localized and can be associated with systemic symptoms like fever.

- Lymphadenopathy: This refers to the enlargement of lymph nodes, which can occur due to infections (viral or bacterial), autoimmune diseases, or malignancies. The swelling is typically more generalized, and the lymph nodes may be tender to touch. Lymphadenopathy can be a response to infections in the head and neck region, including viral infections like the common cold or more serious conditions.

- Mumps: This is a viral infection characterized by swelling of the parotid glands, which can cause pain in the jaw and neck area. While mumps primarily affects the salivary glands, it can also lead to complications such as orchitis or meningitis. The swelling is usually bilateral and accompanied by systemic symptoms like fever and malaise.

The reason for the differing opinions from your doctors may stem from the overlapping symptoms and the need for thorough clinical evaluation. Each physician may have focused on different aspects of your presentation, leading to varied diagnoses.

2. Antibiotic Effectiveness:
- The recurrence of swelling after stopping antibiotics could indicate that the initial treatment was insufficient or that the underlying cause was not adequately addressed. If the infection is bacterial, a longer course of antibiotics may be necessary. However, if the cause is viral (as in the case of mumps), antibiotics would not be effective, and the treatment would focus on supportive care.

3. Choosing Between Amoxicillin and Cefixime:
- Amoxicillin and cefixime are both antibiotics but belong to different classes. Amoxicillin is a penicillin derivative, while cefixime is a cephalosporin. The choice between them depends on the suspected causative organism and its susceptibility to these antibiotics. If your doctor suspects a bacterial infection that is sensitive to amoxicillin, it may be the preferred choice. However, if there is a concern for resistance or a different bacterial profile, cefixime might be more appropriate. Always follow your doctor's guidance on which antibiotic to take.

4. Further Testing:
- Given the persistence of your symptoms, it may be prudent to discuss further diagnostic testing with your healthcare provider. This could include imaging studies (like an ultrasound or CT scan) to evaluate for abscess formation or other complications, as well as blood tests to assess for signs of infection or inflammation. A thorough evaluation can help clarify the diagnosis and guide appropriate treatment.

In summary, while deep neck infections, lymphadenopathy, and mumps can present with overlapping symptoms, they have distinct causes and treatment approaches. It’s essential to work closely with your healthcare provider to monitor your symptoms and adjust treatment as necessary. If your symptoms persist or worsen, seeking further evaluation is advisable to ensure that any serious conditions are ruled out and appropriately managed.

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