Syphilis Treatment Outcomes and Follow-Up Care - Urology

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Syphilis treatment follow-up indicators?


Hello doctor, I was diagnosed with syphilis in 2014 with a high titer.
I underwent treatment with three doses of penicillin in 2014, but during follow-up, my titer was still 1:32, so I received two more doses in 2015.
After that, I did not return for follow-up.
In 2017, during my pregnancy, I found out my titer was 1:16, so as a precaution, I underwent another treatment with three doses, and my titer decreased to 1:8.
I have been continuously monitored, but as of earlier this month, it is still 1:8.
I would like to ask if my titer indicates any infectiousness? I have been trying very hard to treat this, but is it normal to still be at 1:8? My baby's RPR test is negative, but the VDRL is 1:80.
Does this require treatment? I have been using alcohol to clean myself every day; is that effective?

Xiao Qing, 30~39 year old female. Ask Date: 2018/12/01

Dr. Du Shixi reply Urology


Hello: There is a risk of transmission; sexual activity carries risks, and sexual partners should also be tested.
A ratio of 1:4 is considered safer.
If the ratio is 1:8 and does not decrease, it may indicate a chronic infection, and treatment may no longer be effective in reducing the levels.
However, it is essential to regularly monitor the indices, and if there is any increase, treatment should be initiated.
Such conditions require long-term follow-up because symptoms can sometimes be subtle and not easily noticeable.
Regarding the baby's value (VDRL 1:80 being somewhat unusual), please consult a pediatrician about whether treatment is necessary.
Alcohol wipes are ineffective.
Wishing you good health.

Reply Date: 2018/12/01

More Info


Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. The treatment of syphilis typically involves the administration of penicillin, which is highly effective in eradicating the infection. However, monitoring and follow-up care are crucial to ensure that the treatment has been successful and to prevent any potential complications.

In your case, it appears that you have undergone multiple treatments with penicillin, which is the standard approach for syphilis. The fact that your RPR (Rapid Plasma Reagin) titers have decreased from higher levels to 1:8 is a positive sign, indicating that the treatment is having an effect. However, it is important to understand that the RPR test can remain reactive for some time even after successful treatment, especially in cases of late latent syphilis or if there was a significant initial titer.

Regarding your question about infectiousness, a titer of 1:8 does not necessarily indicate that you are still infectious. The risk of transmission is significantly reduced after appropriate treatment, especially if you have completed the recommended course of penicillin. However, it is essential to have regular follow-up appointments with your healthcare provider to monitor your titers and ensure that they continue to decline.

As for your baby, the fact that the RPR test is negative is reassuring. However, the VDRL (Venereal Disease Research Laboratory) test showing a titer of 1:80 suggests that further evaluation may be necessary. It is important to discuss this with your healthcare provider, as they may recommend additional testing or treatment based on the results. In some cases, a positive VDRL in infants can indicate congenital syphilis, and further investigation is warranted.

Regarding the use of alcohol to clean yourself, it is not necessary and does not contribute to the treatment of syphilis. The primary focus should be on ensuring that you complete any prescribed treatment and attend follow-up appointments to monitor your progress. Additionally, practicing safe sex and informing any sexual partners about your history of syphilis is crucial to prevent reinfection and further transmission.

In summary, while your current titer of 1:8 may seem concerning, it is not uncommon for titers to remain reactive for some time after treatment. Regular follow-up with your healthcare provider is essential to monitor your progress and address any concerns. For your baby, further evaluation of the VDRL result is necessary, and it is important to consult with a healthcare provider for appropriate guidance. Remember that maintaining open communication with your healthcare team is key to managing your health effectively.

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