Interactions Between Emergency Contraceptives and Sleep Medications: What You Need to Know - Pharmacology

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The interaction between the emergency contraceptive pill Ella (Ulipristal Acetate) and the oral contraceptive pill Levonorgestrel (commonly known as Plan B)?


Hello, doctor.
I have been taking Yaz (a combined oral contraceptive) for four months without any issues or symptoms.
However, due to recent stress and difficulty sleeping, my doctor prescribed me Lunesta (0.25 mg).
I asked the doctor if there was any interaction, but he vaguely indicated that it should be fine.
This made me feel uneasy, so I wanted to consult a professional.
Thank you for your help!

Jian Xiaoting, 20~29 year old female. Ask Date: 2018/12/26

Dr. Hou Fangmin reply Pharmacology


Hello Ms.
Chien, the interaction between Yuezhi and Brotizolam is classified as moderate, with minimal impact.
It slightly increases the metabolism of the contraceptive pill, resulting in a minor reduction in its effectiveness, but it is not a concern.
Wishing you peace and joy.

Reply Date: 2018/12/26

More Info


When it comes to the interactions between emergency contraceptives, such as the combination pill you are taking (which contains ethinylestradiol and gestodene), and sleep medications like Lorazepam (the medication you referred to as "戀多眠錠"), it is essential to understand how these medications work and their potential interactions.

Emergency contraceptives primarily function by preventing ovulation, fertilization, or implantation of a fertilized egg. They contain hormones that can influence the menstrual cycle and reproductive system. On the other hand, Lorazepam is a benzodiazepine that acts on the central nervous system to produce a calming effect, helping to alleviate anxiety and promote sleep.

In general, there is no direct pharmacological interaction between hormonal contraceptives and Lorazepam. This means that taking Lorazepam should not significantly affect the efficacy of your emergency contraceptive. However, it is crucial to consider the overall impact of combining these medications on your body, especially regarding side effects and how they may affect your mental and physical state.

One of the primary concerns when combining these medications is the potential for increased sedation and central nervous system depression. Both emergency contraceptives and Lorazepam can have side effects, and when taken together, the sedative effects of Lorazepam may be enhanced. This can lead to increased drowsiness, confusion, or impaired coordination, particularly if you are not accustomed to taking benzodiazepines.

Moreover, if you are experiencing significant stress and anxiety, it is essential to address these underlying issues. While Lorazepam can provide short-term relief, it is not a long-term solution for anxiety or sleep disturbances. It is advisable to discuss with your healthcare provider the possibility of exploring other therapeutic options, such as cognitive-behavioral therapy (CBT) or other non-benzodiazepine sleep aids, which may have a lower risk of dependency and fewer side effects.

Additionally, if you are taking other medications or have underlying health conditions, it is vital to inform your healthcare provider. They can assess your overall medication regimen and provide personalized advice based on your specific situation.

In summary, while there is no significant interaction between your emergency contraceptive and Lorazepam, caution is warranted due to the potential for increased sedation. Always consult with your healthcare provider regarding any concerns about medication interactions, especially when introducing new medications into your regimen. They can provide the most accurate and tailored advice to ensure your safety and well-being.

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