Variability in Ultrasound Results for Adrenal Tumors - Urology

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Hello Dr.
Du, I have some questions regarding ultrasound.

1) Since I have a gallbladder polyp, I have been undergoing regular abdominal ultrasound follow-ups, which led to the discovery of an adrenal tumor.
I would like to know if the results of an ultrasound can vary depending on the operator performing the procedure.
2) Regarding my adrenal tumor, it was first detected by a gastroenterologist during an abdominal ultrasound.
Subsequently, I underwent a CT scan and urine tests for diagnosis by an endocrinologist.
Six months later, in April 2018, I had an MRI follow-up, and then in early August of last year, during a routine abdominal ultrasound (for gallbladder polyp follow-up), the measurement was consistently 2.6 cm.
However, in late August, during a renal ultrasound at Shuitian Urology, the technician reported the adrenal tumor as 2.2 cm, while the renal tumor was noted as 0.6 cm.
I would like to understand why the measurement of the adrenal tumor was 2.6 cm at Tai-An, then 2.2 cm at Shuitian, and upon returning to Tai-An for a kidney examination, the renal tumor was measured at 0.68 cm, but the adrenal tumor increased to 2.9 cm.
3) Follow-up visits are essential, but the fluctuating tumor measurements can be quite distressing.
Thank you again for your patience.

Er Mao, 50~59 year old female. Ask Date: 2019/01/11

Dr. Du Shixi reply Urology


Hello: In Western medicine, nothing is absolute.
There are many brands of equipment and variations in the habits of the operators, which can lead to differences that are often observed.
Therefore, it is advisable to have tests conducted at a single medical center for comparative value; otherwise, the results can only serve as a reference.
Wishing you good health.

Reply Date: 2019/01/11

More Info


Understanding variability in ultrasound results, particularly for adrenal tumors, is a common concern among patients undergoing regular imaging studies. The discrepancies in measurements and findings can be attributed to several factors, including the operator's technique, the equipment used, and the inherent variability in tumor characteristics over time.

1. Operator Variability: Ultrasound is a highly operator-dependent imaging modality. Different technicians or physicians may have varying levels of experience and expertise, which can lead to differences in how they perform the ultrasound and interpret the results. Factors such as the angle of the ultrasound probe, the pressure applied, and the patient's position during the examination can all influence the quality of the images obtained. Additionally, the subjective nature of interpreting ultrasound images means that one operator may perceive a lesion differently than another. This is why it is often recommended to have follow-up ultrasounds performed at the same facility or by the same operator whenever possible to ensure consistency in imaging and interpretation.

2. Tumor Measurement Variability: The size of adrenal tumors can appear to fluctuate between imaging studies due to several reasons. First, the measurement technique can vary; for example, some operators may measure the longest diameter of the tumor, while others may measure the shortest axis. This can lead to discrepancies in reported sizes. Additionally, the tumor may not be a solid mass but rather a complex structure that can change in appearance based on the imaging angle or the patient's body habitus. Furthermore, tumors can undergo changes over time, such as growth or regression, which may be influenced by hormonal factors or treatment interventions. In your case, the reported sizes of your adrenal tumor varied between 2.2 cm and 2.9 cm, which could be due to these factors.

3. Importance of Consistent Follow-Up: Regular follow-up imaging is crucial for monitoring adrenal tumors. It helps in assessing any changes in size or characteristics that may indicate a need for further evaluation or intervention. The fluctuations in tumor size that you have experienced can understandably cause anxiety, but it is essential to remember that not all changes indicate malignancy or aggressive behavior. In many cases, benign adrenal tumors, such as adenomas or pheochromocytomas, can remain stable over time.
In conclusion, while variability in ultrasound results can be concerning, it is important to approach these findings with a comprehensive understanding of the factors involved. Consistent follow-up with your healthcare provider, who can interpret these results in the context of your overall health and any symptoms you may be experiencing, is key. If there are significant changes or concerns regarding the nature of the tumor, further diagnostic evaluations, such as CT scans or MRIs, may be warranted to provide a clearer picture. Always feel free to discuss your concerns with your healthcare team, as they can provide reassurance and guidance tailored to your specific situation.

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