Chlamydia Test Results: Positive IgG & IgA but No Infection? - Urology

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Hello Doctor, I recently had a test at a laboratory that showed Chlamydia IgG: 1.11, IgA: 1.41, and IgM: 0.12.
Both IgG and IgA were positive (above 1.1).
The technician recommended that I see a doctor for treatment.
I have visited two major hospitals; one doctor looked at the report and told me to go home, saying there was nothing to worry about and that the laboratory was unreliable, claiming that such blood tests have no reference value.
The other hospital's doctor retested for Chlamydia, and while IgG and IgA remained positive, the Chlamydia RNA in my urine was negative.
Therefore, they concluded that the Chlamydia test was negative and that no treatment was necessary.
Both doctors stated that I do not have an infection and that I do not need medication, with one even refusing to retest and telling me to go home and not worry.

I would like to ask the doctor why my Chlamydia IgG and IgA would still be positive if I do not have an infection.
If I had been infected in the past but have not taken any antibiotics since adulthood, can Chlamydia resolve on its own? I am quite curious because online medical resources indicate that positive IgG and IgA suggest a past infection, and there is a high likelihood of being asymptomatic.
I am really confused right now.
Thank you.

Niming, 30~39 year old female. Ask Date: 2019/02/01

Dr. Du Shixi reply Urology


Hello: The detection of Chlamydia IgG & IgA is not conclusive; it has some reference value but is not high.
To confirm the diagnosis, specimens from the affected area (such as urogenital secretions or urine) must be collected, and PCR methods should be used to detect the presence of pathogen ribosomal RNA.
The report is generally expressed as positive or negative, which is more reliable.
Therefore, it cannot be stated that you have a diagnosis of Chlamydia infection; please trust the diagnosis made by the physicians at the major hospital.
Information found online may be outdated or incorrect.
Wishing you good health.

Reply Date: 2019/02/01

More Info


Understanding the results of Chlamydia tests, particularly the IgG and IgA antibodies, can indeed be confusing, especially when faced with conflicting medical opinions. Let's break down your situation and clarify the implications of your test results.


Interpretation of IgG and IgA Results
1. Understanding Antibodies:
- IgG antibodies indicate past exposure to the Chlamydia bacteria. If your IgG level is elevated (1.11 in your case), it suggests that you have been exposed to Chlamydia at some point in the past. However, it does not necessarily mean that you currently have an active infection.

- IgA antibodies are less commonly discussed but can indicate a more recent infection or an immune response to the bacteria. An elevated IgA level (1.41) could suggest a more recent exposure, but again, it does not confirm an active infection.

2. Negative RNA Test:
- The urine test for Chlamydia RNA being negative is a crucial piece of information. This indicates that there is no active infection at the time of testing. The presence of IgG and IgA without a corresponding positive RNA test suggests that while you may have been exposed to the bacteria in the past, your body has either cleared the infection or you are not currently infected.


Why Are Antibodies Present Without Current Infection?
- Natural Resolution: It is possible for the body to clear a Chlamydia infection without treatment, especially if it was a mild or asymptomatic case. The immune system can effectively fight off the infection, leading to the presence of antibodies (IgG and IgA) without any active disease.

- Previous Infection: If you had a Chlamydia infection in the past, your body would produce IgG antibodies as part of the immune response. These antibodies can remain in the bloodstream for a long time, even after the infection has resolved.


Conflicting Medical Opinions
- The differing opinions from the healthcare providers you consulted highlight a common issue in the interpretation of serological tests. Some physicians may rely more heavily on the presence of antibodies, while others may prioritize the results of direct testing (like the RNA test) to determine the need for treatment.

- The recommendation to not treat you, especially in light of a negative RNA test, aligns with the understanding that you do not have an active infection. This is a reasonable approach, as unnecessary antibiotic treatment can lead to resistance and other complications.


Recommendations
1. Follow-Up Testing: If you remain concerned about your Chlamydia status, consider discussing with your healthcare provider the possibility of follow-up testing in a few months. This can help confirm that your antibody levels are stable or declining, indicating no ongoing infection.

2. Monitor Symptoms: If you develop any symptoms suggestive of a Chlamydia infection (such as unusual discharge, pain during urination, or pelvic pain), seek medical attention promptly.

3. Education: Continue to educate yourself about sexually transmitted infections (STIs) and their implications. Understanding the nature of these infections can help alleviate anxiety and empower you to make informed decisions about your health.


Conclusion
In summary, your elevated IgG and IgA levels suggest past exposure to Chlamydia, but the negative RNA test indicates that you do not have an active infection. The body can clear infections naturally, and the presence of antibodies alone does not necessitate treatment. It's important to maintain open communication with your healthcare providers and to seek further clarification if needed. Your health and peace of mind are paramount, and understanding your test results is a crucial step in managing your sexual health.

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