Pregnancy and Contraception Concerns for Lupus Patients - Obstetrics and Gynecology

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Pregnancy and Contraception Issues in Systemic Lupus Erythematosus


Hello, doctor.
As mentioned in the subject, I am currently a patient with systemic lupus erythematosus (SLE) and take quinine daily.
I would like to ask about contraceptive options for SLE patients, as it seems that the use of oral contraceptives, especially those that increase estrogen, is not recommended.
What types of contraceptives are more advisable? Additionally, if I wish to prevent fetal development after fertilization, what medications can be used that would not harm my body?

Ms. Huang, 20~29 year old female. Ask Date: 2019/02/28

Dr. Huang Jianzhong reply Obstetrics and Gynecology


Currently, for patients with systemic lupus erythematosus (SLE) who are taking quinine daily, it seems that oral contraceptives, especially those that increase estrogen, are not recommended.
What types of contraceptives are more advisable? Answer: Mechanical contraceptive methods such as condoms and intrauterine devices (IUDs) are recommended.
Additionally, if one wishes to prevent the continuation of fetal development after fertilization, what medications can be used that are less harmful to the body? Answer: To prevent fetal development after fertilization, RU486 may be an option, but it can be harmful to the body.

Reply Date: 2019/02/28

More Info


When it comes to managing pregnancy and contraception for patients with Systemic Lupus Erythematosus (SLE), there are several important considerations to keep in mind. SLE is an autoimmune disease that can complicate both pregnancy and contraceptive choices due to its effects on the body and the potential risks associated with certain medications.

First and foremost, it is true that many healthcare providers recommend caution when it comes to the use of hormonal contraceptives, particularly those that contain estrogen, in women with SLE. This is primarily due to the increased risk of thromboembolic events (blood clots) associated with estrogen-containing contraceptives, which can be particularly concerning for lupus patients who may already have a higher risk of clotting due to their condition. Therefore, non-hormonal methods of contraception are often preferred.
Some recommended contraceptive options for women with SLE include:
1. Barrier Methods: These include condoms, diaphragms, and cervical caps. They are effective in preventing pregnancy without the hormonal risks associated with oral contraceptives.

2. Intrauterine Devices (IUDs): Both hormonal and non-hormonal IUDs can be effective options. The non-hormonal copper IUD is particularly appealing as it does not involve hormones, thus avoiding any potential complications related to SLE.

3. Implants: Hormonal implants may be considered, but it is essential to discuss the risks and benefits with a healthcare provider, as they can still carry some risk of thromboembolic events.

4. Natural Family Planning: This method involves tracking the menstrual cycle and identifying fertile days to avoid intercourse during that time. While it requires diligence and understanding of one’s body, it is a hormone-free method.

Regarding your question about medications to terminate a pregnancy after fertilization, it is crucial to approach this topic with caution. The use of medications for abortion, such as mifepristone and misoprostol, should only be considered under the guidance of a qualified healthcare provider. These medications can have side effects and may not be suitable for all patients, especially those with underlying health conditions like lupus. Additionally, the safety and efficacy of these medications in the context of lupus have not been extensively studied, and there may be risks involved.

If you are considering pregnancy or are currently pregnant, it is vital to have a thorough discussion with your healthcare provider, preferably one who specializes in high-risk pregnancies or rheumatology. They can provide personalized advice based on your specific health status, the severity of your lupus, and any medications you are currently taking.

In summary, for women with SLE, non-hormonal contraceptive methods are generally recommended to avoid the risks associated with estrogen. If pregnancy is a consideration, it is essential to have a comprehensive care plan in place to monitor both maternal and fetal health. Always consult with your healthcare provider before making any decisions regarding contraception or pregnancy management to ensure the best outcomes for both you and your potential future child.

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