Measles Antibody Thresholds: Risks and Recommendations

Q: Measles Antibody Thresholds: Risks and Recommendations

Dear Mr. Anonymous： 1. Generally speaking, the results of antibody tests yield a numerical value. If this value exceeds a specific threshold, it is referred to as a positive reaction; sometimes it is also called reactive. Conversely, if the value is below a cer

Antibody threshold value

Hello, doctor.
I work at the airport and need to check my measles antibodies.
The report shows that my measles antibody level is at the borderline.
The company has arranged for me to get vaccinated! I have a couple of questions: 1.
Does "borderline" mean that the level is at the edge of the normal range or close to zero? 2.
Will I be at a high risk of infection during the time before I receive the vaccine, considering my antibody level is borderline? Thank you for your help.

Niming, 20~29 year old female. Ask Date: 2019/03/07

Dr. Xiao Yongxun reply Family Medicine

Dear Mr.
Anonymous:
1.
Generally speaking, the results of antibody tests yield a numerical value.
If this value exceeds a specific threshold, it is referred to as a positive reaction; sometimes it is also called reactive.
Conversely, if the value is below a certain threshold, it is termed a negative reaction; occasionally referred to as non-reactive.
The term borderline typically refers to a value that is very close to that specific threshold.
It is advisable for you to consult your company's occupational health nurse or company physician with your test report.
2.
Theoretically, a test value close to the specific threshold indicates that antibody levels may be insufficient; it may also suggest that the memory of the antibodies could be lacking.
In such cases, if the virus invades the individual, the production of antibodies may not be adequate to combat the viral attack, potentially leading to illness.
Of course, immune responses can vary from person to person; it is possible that even with a test value near the threshold, an individual may still produce a significant amount of antibodies upon viral invasion, demonstrating robust immune memory.
3.
Your company's arrangement for a booster shot is correct; that is, administering a booster vaccination to ensure adequate antibody production, which serves to protect the individual and prevent outbreaks of infectious diseases.
4.
If you have further questions, please consult your company's occupational health nurse or company physician.

Reply Date: 2019/03/07

More Info

Hello! Thank you for your questions regarding measles antibody thresholds and the associated risks. Understanding these thresholds is crucial, especially for someone working in an environment like an airport where exposure to infectious diseases can be higher.

1. Understanding Marginal Values: When your report indicates that your measles antibody levels are at the "marginal" value, it typically means that your antibody levels are close to the lower limit of what is considered protective. In most laboratory settings, this means that your levels are not definitively within the normal range, but they are not zero either. The exact interpretation can vary by laboratory, but generally, a marginal result suggests that you may not have sufficient immunity to fully protect you against measles.
2. Risk of Infection: Given that your antibody levels are marginal, there is a potential risk of infection until you receive the booster vaccination. The measles virus is highly contagious, and individuals with marginal or low antibody levels may not be adequately protected. The risk of infection is especially pertinent in crowded places like airports, where the likelihood of encountering someone with measles could be higher.
Measles is a viral infection that can lead to serious complications, including pneumonia, encephalitis, and even death. The virus is airborne and can remain in the air for up to two hours after an infected person has left the area. Therefore, it is advisable to take precautions while you wait for your vaccination.
Recommendations:
- Vaccination: Since your company has already arranged for you to receive the measles vaccine, it is crucial to follow through with this as soon as possible. The measles vaccine is highly effective, and receiving it will significantly boost your immunity.

- Avoid Crowded Places: Until you are vaccinated, try to minimize your exposure to crowded areas, especially where there is a known outbreak of measles or where vaccination rates are low.

- Monitor Symptoms: Be vigilant for any symptoms of measles, which include high fever, cough, runny nose, and a characteristic rash. If you experience any of these symptoms, seek medical attention immediately.

- Consult Your Healthcare Provider: If you have any concerns about your health or the timing of your vaccination, it’s a good idea to consult with your healthcare provider. They can provide personalized advice based on your health history and current situation.

In summary, having marginal measles antibody levels indicates that you may not be fully protected against the virus, and it is wise to take precautions until you receive your vaccination. The measles vaccine is a safe and effective way to ensure you are protected against this serious disease. Stay safe, and thank you for taking proactive steps to protect your health and the health of those around you!

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