the Impact of RU486 on Early Pregnancy: Your Questions Answered - Obstetrics and Gynecology

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Regret after a medical abortion?


Hello doctor, I am nearly five weeks pregnant and have taken the first dose of RU486 without any symptoms.
The pregnancy test shows a darker line.
Can the embryo still remain viable? Does taking the first dose affect the embryo? Can an ultrasound determine if the embryo has shrunk?

LALA, 30~39 year old female. Ask Date: 2019/03/18

Dr. Huang Jianzhong reply Obstetrics and Gynecology


At nearly five weeks of pregnancy, taking the first dose of RU486 without any symptoms and seeing a darker pregnancy test result—can the embryo still remain? Answer: It is possible that the embryo can still remain.
Does taking the first dose affect the embryo? Answer: The effect could lead to a miscarriage.
Can an ultrasound determine if the embryo has shrunk? Answer: It should be able to.

Reply Date: 2019/03/18

More Info


RU486, also known as mifepristone, is a medication commonly used for medical abortion. It works by blocking the hormone progesterone, which is essential for maintaining a pregnancy. When taken in the early stages of pregnancy, RU486 can lead to the detachment of the embryo from the uterine lining, resulting in a miscarriage.
In your case, you are approaching five weeks of pregnancy and have taken the first dose of RU486 without experiencing any symptoms. It is important to understand that the effectiveness of RU486 can vary from person to person. While some may experience immediate effects, others may not notice significant changes right away. The fact that your pregnancy test is showing a darker line indicates that the hormone hCG (human chorionic gonadotropin) is still present, which suggests that the pregnancy is still ongoing at this point.

Regarding your question about whether the embryo can still be retained after taking the first dose of RU486, it is possible. The first dose alone does not guarantee that the pregnancy will terminate. Many women have continued their pregnancies after taking RU486, although this is not the intended use of the medication. If the embryo has not detached or if the body has not responded to the medication, it may still be viable.
As for whether an ultrasound can detect if the embryo has stopped developing (or "atrophied"), this typically depends on the timing of the ultrasound. At around five weeks, it may be too early to see significant changes on an ultrasound. Generally, a transvaginal ultrasound is more sensitive and can detect early pregnancy changes better than an abdominal ultrasound. If the pregnancy is still ongoing, the ultrasound may show a gestational sac, and possibly a fetal pole, but it may not provide definitive answers about the health of the embryo at this early stage.

If you are considering continuing the pregnancy, it is crucial to consult with your healthcare provider. They can offer guidance based on your specific situation and may recommend monitoring your hCG levels or scheduling a follow-up ultrasound to assess the status of the pregnancy.
In summary, while taking RU486 can initiate the process of abortion, it does not always result in the termination of pregnancy after the first dose. If you are experiencing no symptoms and your pregnancy test remains positive, there is a possibility that the embryo is still viable. It is essential to communicate openly with your healthcare provider about your concerns and intentions regarding the pregnancy, as they can provide the best advice tailored to your situation.

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