Esophageal Issues: Symptoms and Risks of Ulcers and Perforations - Otolaryngology

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Esophageal issues?


Hello Doctor, I recently came across an article about someone who developed esophageal ulcers after swallowing acne antibiotics and lying down immediately.
I realized that I had also been lying down right after taking my medication, just like the person in the article.
I would like to ask, since I changed my medication timing and habits nearly two months ago, can esophageal ulcers or perforations occur without symptoms? Or could they develop chronically? I am a bit worried because I read that esophageal perforation is an emergency that can be fatal.
Thank you for taking the time to reply.

JAM, 20~29 year old female. Ask Date: 2019/03/19

Dr. Zheng Jueyi reply Otolaryngology


Hello: Esophageal ulcers and perforations often present with symptoms such as difficulty swallowing, hematemesis, or acute fever, typically occurring as acute episodes.
If there are no obvious symptoms, observation may be sufficient.
It is recommended to take medications with plenty of water and to avoid dry swallowing of pills.
Wishing you safety and health.
Sincerely, Dr.
Jue-Yi Cheng, Director of the Department of Otolaryngology, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2019/03/19

More Info


Esophageal ulcers and perforations are serious medical conditions that can arise from various factors, including medication misuse, chronic gastroesophageal reflux disease (GERD), and other underlying health issues. Understanding the symptoms, risks, and management of these conditions is crucial for maintaining esophageal health.

Symptoms of Esophageal Ulcers:
Esophageal ulcers can develop due to the erosion of the esophageal lining, often resulting from prolonged exposure to irritants such as stomach acid or certain medications. Common symptoms include:
- Dysphagia: Difficulty swallowing, which may be accompanied by pain.

- Odynophagia: Painful swallowing, often described as a burning sensation.

- Chest Pain: This can mimic heart-related issues and may be severe.

- Regurgitation: The sensation of food or liquid coming back up into the throat or mouth.

- Weight Loss: Due to pain while eating or difficulty swallowing, individuals may unintentionally lose weight.

Symptoms of Esophageal Perforation:
Esophageal perforation is a medical emergency characterized by a tear in the esophagus. Symptoms may include:
- Severe Chest Pain: This pain is often sudden and intense, radiating to the back or shoulders.

- Fever and Chills: Indicating possible infection or systemic response.

- Shortness of Breath: Due to mediastinal involvement or pleural effusion.

- Subcutaneous Emphysema: Air escaping into the soft tissues, leading to swelling and a crackling sensation upon palpation.

Chronic vs. Acute Symptoms:
In some cases, esophageal ulcers can develop slowly and may not present noticeable symptoms until they become severe. Chronic ulcers may lead to intermittent discomfort, which can be mistaken for less serious conditions. Conversely, perforations typically present acutely and require immediate medical attention.

Risks Associated with Esophageal Ulcers and Perforations:
- Medication Misuse: As you mentioned, taking certain medications while lying down can increase the risk of esophageal ulcers. Antibiotics, particularly tetracyclines, can irritate the esophagus if they do not reach the stomach quickly.

- Chronic GERD: Long-standing acid reflux can damage the esophagus, leading to ulcers and increasing the risk of perforation.

- Infections: Certain infections can weaken the esophageal lining, making it more susceptible to ulcers.

- Tumors: Malignancies can also lead to ulceration and perforation.

Management and Prevention:
1. Medication Administration: Always take medications with sufficient water and remain upright for at least 30 minutes afterward to minimize the risk of irritation.

2. Dietary Modifications: Avoid foods that exacerbate reflux, such as spicy, acidic, or fatty foods. Eating smaller, more frequent meals can also help.

3. PPI Therapy: Proton pump inhibitors (PPIs) can reduce stomach acid production, aiding in the healing of ulcers and preventing further damage.

4. Regular Monitoring: If you have a history of esophageal issues, regular check-ups with a gastroenterologist are essential for monitoring and managing your condition.

When to Seek Medical Attention:
If you experience severe chest pain, difficulty swallowing, or any signs of perforation (such as sudden severe pain, fever, or difficulty breathing), seek immediate medical care. Early intervention can be life-saving.

In conclusion, while esophageal ulcers can sometimes be asymptomatic or present with mild symptoms, it is essential to remain vigilant, especially if you have risk factors. Regular follow-ups with your healthcare provider and adherence to safe medication practices can significantly reduce the risk of developing serious complications like ulcers and perforations.

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