Do Cold Medications Interfere with Birth Control Pills? - Obstetrics and Gynecology

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Will taking these cold medications interfere with oral contraceptives?


I started taking my first oral contraceptive pill on April 8.
On April 19, I caught a cold and saw a doctor the next day, April 20, where I took a pack of medication and a vitamin C tablet.
However, in the afternoon of April 20, I had unprotected intercourse with ejaculation.
I would like to know if these medications will affect the effectiveness of the contraceptive pill.
I took Ibuprofen, Cephalexin, Magocain, and Locemine.
I just checked the medication list, and Cephalexin is an antibiotic; I only took one pack of cold medicine, and there was a 10-hour gap before I took the contraceptive pill again.
I'm unsure if this will impact the contraceptive effectiveness.
Thank you.

Qi Qi, 10~19 year old female. Ask Date: 2019/04/20

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I started taking my first oral contraceptive on April 8.
On April 19, I caught a cold and the next day, April 20, I saw a doctor and took a pack of medication along with a vitamin C tablet.
However, in the afternoon of April 20, I had unprotected intercourse and ejaculation occurred.
I would like to know if these medications will affect the effectiveness of the contraceptive pill.
I took Ibuprofen, Cephalexin, Magocain, and Locemine.
I just checked the medication list, and Cephalexin is an antibiotic; I only took one pack of cold medicine, and I took the contraceptive pill 10 hours later.
Will this affect the contraceptive effectiveness? Answer: No, it will not affect the contraceptive effectiveness.

Reply Date: 2019/04/20

More Info


When it comes to the interaction between cold medications and birth control pills, it's essential to understand how different medications can affect hormonal contraceptives. In your case, you mentioned taking ibuprofen, cephalexin, and a cold medication, along with vitamin C, after starting your birth control pill on April 8th. You also had unprotected intercourse on April 20th.

First, let's address the medications you took:
1. Ibuprofen: This is a non-steroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and reduce inflammation. There is no evidence to suggest that ibuprofen affects the efficacy of birth control pills.

2. Cephalexin: This is an antibiotic that belongs to the cephalosporin class. While some antibiotics can interfere with the effectiveness of hormonal contraceptives, cephalexin is generally not one of them. The primary concern with antibiotics and birth control is with certain types, particularly rifampin and rifabutin, which are known to reduce the effectiveness of hormonal contraceptives. Since cephalexin does not fall into this category, it should not affect your birth control.

3. Cold Medications: The specific ingredients in the cold medication you took are crucial to determine any potential interactions. Many over-the-counter cold medications do not affect birth control pills. However, some formulations may contain ingredients that could theoretically impact absorption or metabolism, but these instances are rare.

4. Vitamin C: Taking vitamin C does not have any known interactions with birth control pills.

Given that you took the birth control pill approximately 10 hours after consuming the cold medication and cephalexin, it is unlikely that the timing would significantly impact the effectiveness of the pill. Birth control pills are designed to maintain their efficacy even with some variations in timing, as long as they are taken consistently and correctly.

In summary, based on the medications you mentioned, there is no substantial evidence to suggest that they would interfere with the effectiveness of your birth control pills. However, it is always advisable to consult with your healthcare provider or pharmacist regarding any specific concerns about medication interactions, especially when it comes to contraceptive efficacy.
If you are worried about the possibility of pregnancy due to unprotected intercourse, consider taking a home pregnancy test if your period is late or consult your healthcare provider for further guidance. Additionally, if you find yourself frequently needing to take medications that could potentially interact with your birth control, discussing alternative contraceptive methods with your healthcare provider may be beneficial.
Lastly, always remember that while hormonal contraceptives are highly effective, they do not protect against sexually transmitted infections (STIs), so using condoms is recommended for additional protection.

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