Missed Period and Nausea After Stopping Menstrual Medication: Possible Causes - Obstetrics and Gynecology

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It has been two weeks since taking the contraceptive pill, and I am feeling nauseous?


Hello doctor, I started taking the contraceptive pill on April 12 and stopped on April 21, but my period still hasn't arrived.
However, I have been experiencing breast tenderness and, in the past week, I've felt bloated and nauseous.
Could this be a sign of pregnancy, or is it just a side effect? If I'm not pregnant, why hasn't my period returned after three weeks of stopping the medication? Thank you!

Xiao Xiao, 20~29 year old female. Ask Date: 2019/05/13

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I started taking the medication on April 12 and stopped on April 21, but my period still hasn't arrived.
However, I have been experiencing breast tenderness and, in the past week, I've felt bloated and nauseous.
Am I pregnant, or could this just be a side effect? If I'm not pregnant, why hasn't my period come back after stopping the medication for three weeks? Answer: Take a pregnancy test to check.

Reply Date: 2019/05/13

More Info


When a person stops taking menstrual medications, such as hormonal contraceptives or medications designed to regulate menstrual cycles, it is not uncommon to experience changes in their menstrual cycle. The symptoms you are describing—missed periods, breast tenderness, and nausea—can be attributed to several factors, including hormonal fluctuations, potential pregnancy, or side effects from the medication itself.

Firstly, it is important to consider the possibility of pregnancy. If you have engaged in unprotected sexual intercourse after stopping the medication, it is advisable to take a home pregnancy test. Hormonal contraceptives work by altering the natural hormonal balance in the body, and stopping them can lead to a temporary disruption in your menstrual cycle. This disruption can sometimes result in a missed period, especially if your body is still adjusting to the absence of the hormones provided by the medication.

Breast tenderness is a common symptom associated with hormonal changes. When you stop taking hormonal medications, your body may take some time to readjust to its natural hormonal levels, which can lead to symptoms such as breast pain or swelling. Similarly, nausea and gastrointestinal discomfort can also be side effects of hormonal fluctuations. Some women may experience these symptoms as their bodies respond to the sudden change in hormone levels after discontinuation of the medication.

If you have not had a period for three weeks after stopping the medication, it could be due to several reasons:
1. Hormonal Imbalance: After stopping hormonal medications, your body may take time to restore its natural hormonal rhythm. This can lead to irregularities in your menstrual cycle, including delayed periods.

2. Ovulation: Depending on your individual hormonal profile, ovulation may be delayed after stopping the medication. If ovulation does not occur, menstruation will not follow.

3. Stress and Lifestyle Factors: Stress, changes in weight, diet, and exercise can also impact your menstrual cycle. If you have experienced significant stress or changes in your lifestyle recently, this could contribute to a missed period.

4. Underlying Health Conditions: Conditions such as polycystic ovary syndrome (PCOS), thyroid disorders, or other hormonal imbalances can also affect menstrual regularity. If you have a history of such conditions, it may be worth discussing with your healthcare provider.

In summary, while it is possible that you could be pregnant, it is also likely that your body is adjusting to the cessation of hormonal medication, leading to the symptoms you are experiencing. If you are concerned about the possibility of pregnancy or if your symptoms persist, it is important to consult with a healthcare professional. They can provide a thorough evaluation, including a pregnancy test and possibly further hormonal assessments, to determine the underlying cause of your symptoms and missed period. Additionally, they can guide you on the best course of action moving forward, whether that involves waiting for your cycle to normalize or exploring other treatment options.

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