Post-Oophorectomy Medication Choices: Managing Menstrual Symptoms - Obstetrics and Gynecology

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Last year, I underwent a bilateral oophorectomy and salpingectomy due to a bacterial infection, so I should no longer have menstruation, right? After the surgery, my attending physician did not conduct any additional tests and only mentioned two medication options: one that would stop menstruation (Bremelanotide) and another that would cause a pseudomenstruation (I don't know the name of this medication).
I chose Bremelanotide and have been taking it for about six months, but I experienced a menstrual period in March and now I have had a second one.
Additionally, I previously had surgery for endometriosis, and now I am experiencing dysmenorrhea.
I would like to know if it is less suitable for me to take this medication, and whether I should consider the one that causes pseudomenstruation instead, or if it is possible to not take any medication at all.
Thank you for your assistance.

Chen Xuan, 30~39 year old female. Ask Date: 2019/05/14

Dr. Huang Yuande reply Obstetrics and Gynecology


After bilateral salpingo-oophorectomy, menstruation will cease; however, if female hormones are supplemented, the endometrium may still proliferate due to stimulation, resulting in menstrual-like bleeding, which is normal.
Nonetheless, the medication may also stimulate abnormal endometrial growth in the uterine body, leading to potential complications.
The management of the medication should be adjusted by a physician, so it is advisable to discuss this with a specialist in obstetrics and gynecology.

Reply Date: 2019/05/14

More Info


After undergoing a bilateral oophorectomy (removal of both ovaries) and salpingectomy (removal of the fallopian tubes), it is indeed expected that menstruation would cease, as the primary source of estrogen and progesterone production is removed. However, there are instances where patients may experience breakthrough bleeding or pseudo-menstruation even after such surgeries, particularly if hormone replacement therapy (HRT) is involved.

In your case, you mentioned that you have been taking "Banlena" (likely a brand name for a hormonal medication) for over six months, and you have experienced menstrual-like bleeding twice since starting the medication. This situation can be concerning, especially given your history of endometriosis and chocolate cysts, which can complicate hormonal treatments.

The two medications your doctor mentioned likely refer to different types of hormone therapies. One may be a combination of estrogen and progestin, which can sometimes lead to withdrawal bleeding, mimicking a menstrual cycle. The other option, which you did not catch the name of, might be a progestin-only therapy or a different formulation that could help manage symptoms without inducing a monthly cycle.


Considerations for Medication Choices:
1. Understanding the Medications:
- Banlena (likely a form of combined hormonal therapy) can help manage symptoms such as hot flashes, mood swings, and other menopausal symptoms. However, it can also lead to breakthrough bleeding, especially in the initial months of use.

- The alternative medication that induces "pseudo-menstruation" may provide more stable hormone levels and reduce the likelihood of breakthrough bleeding.
2. Evaluating Your Symptoms:
- Given your history of chocolate cysts and the pain associated with them, it is crucial to discuss your symptoms with your healthcare provider. If you are experiencing significant pain or discomfort, it may indicate that the current medication is not suitable for you.

- If the bleeding is accompanied by severe pain, it could suggest a resurgence of endometriosis or other complications that need to be addressed.

3. Consulting Your Doctor:
- It is essential to have a thorough discussion with your physician about your experiences on Banlena. They may recommend switching to the other medication or adjusting your current dosage.

- Additionally, if you are considering not taking any medication, it is vital to weigh the benefits and risks. Hormonal therapy can help alleviate menopausal symptoms, but if you are experiencing adverse effects, a non-hormonal approach may be appropriate.

4. Monitoring and Follow-Up:
- Regular follow-ups with your healthcare provider are essential to monitor your symptoms and adjust treatment as necessary. They may also suggest imaging studies or other evaluations to rule out any complications related to your previous surgeries.

5. Lifestyle and Support:
- In addition to medication, consider lifestyle modifications such as diet, exercise, and stress management techniques, which can also help manage symptoms post-oophorectomy.

In conclusion, while it is common to experience some irregularities after oophorectomy, persistent or painful symptoms warrant further evaluation. Open communication with your healthcare provider will ensure that you receive the most appropriate treatment tailored to your specific needs and medical history.

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