Can Vaccination Trigger Keloid Formation in Patients with Keloid Scars?

Vaccination for individuals with keloid-prone skin?

Hello Doctor: I have a keloid tendency and currently have five keloid scars on my body.
If I receive the cervical cancer vaccine, will the injection site develop a new keloid?

Yang, 20~29 year old female. Ask Date: 2019/05/15

Dr. Wu Yuxin reply Dermatology

Generally, the BCG vaccine is more commonly administered, while the cervical cancer vaccine is less frequently given.

Reply Date: 2019/05/15

More Info

Vaccination can indeed trigger keloid formation in individuals who have a predisposition to keloids, such as those with a history of keloid scars. Keloids are a type of raised scar that occurs when the body produces too much collagen during the healing process. They can develop after skin injuries, including surgical incisions, cuts, or even vaccinations.
In your case, since you have a known history of keloid formation, it is possible that the injection site for the cervical cancer vaccine could lead to the development of a new keloid scar. This risk is particularly pertinent if you have had previous keloids that developed after minor skin trauma. The mechanism behind this phenomenon is not entirely understood, but it is believed that individuals with keloid-prone skin have an abnormal response to injury, leading to excessive collagen deposition.

When considering vaccination, it is essential to weigh the benefits against the potential risks. Vaccines, including the cervical cancer vaccine, are crucial for preventing serious diseases, and the benefits of vaccination often outweigh the risks of keloid formation. However, it is advisable to take certain precautions to minimize the risk of keloid formation at the injection site.
Here are some recommendations:
1. Consult with a Dermatologist: Before proceeding with the vaccination, consult with a dermatologist who is familiar with your keloid history. They can provide personalized advice and may suggest preventive measures.

2. Use of Steroids: Some practitioners may recommend the use of topical or intralesional corticosteroids at the injection site before and after vaccination to help reduce inflammation and the risk of keloid formation.

3. Proper Aftercare: After receiving the vaccine, follow proper aftercare instructions. Keep the injection site clean and avoid any unnecessary trauma to the area.

4. Monitoring: After vaccination, monitor the injection site closely for any signs of abnormal healing, such as excessive redness, swelling, or raised scar formation. If you notice any concerning changes, contact your healthcare provider promptly.

5. Alternative Vaccination Methods: In some cases, alternative vaccination methods, such as using a smaller gauge needle or different injection techniques, may be discussed with your healthcare provider to minimize trauma to the skin.

In summary, while there is a risk of keloid formation at the vaccination site for individuals with a history of keloids, the decision to proceed with vaccination should be made in consultation with healthcare professionals. They can help you assess the risks and benefits and implement strategies to minimize the likelihood of developing new keloids. Vaccination is an essential public health measure, and with appropriate precautions, you can still protect yourself from preventable diseases while managing your keloid risk.

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