Allergy Eye Drops: Emedastine Difumarate and Its Effects - Pharmacology

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Hello Doctor, I recently treated my conjunctivitis with steroid eye drops for about two weeks, and I have completed the treatment.
However, I have a history of eye allergies and the doctor prescribed me an allergy eye drop.
I would like to ask about the active ingredient in Aimin Dine Eye Drops, which is Emedastine Difumarate 2.5g/5ml/bottle, primarily indicated for allergic conjunctivitis symptoms, with the health insurance code BC228564211.

1.
Does this eye drop contain steroids?
2.
Are there any side effects? What is the likelihood of experiencing side effects? Are the side effects reversible after discontinuation?
3.
I am currently experiencing blurred vision in my left eye when looking at distant objects; should I continue using the drops? (I have undergone a dilated eye exam with no issues.)
4.
Will using the drops cause my vision to become more blurred?

Xuan, 20~29 year old female. Ask Date: 2019/06/15

Dr. Hong Kunyi reply Pharmacology


Hello, Miss: Regarding your inquiries: 1.
Emadine (active ingredient: Emedastine Difumarate 2.5mg/5ml/bottle) is steroid-free.
2.
In a clinical study lasting 42 days, the most common side effect was headache (11%), while other side effects such as vivid dreams, fatigue, altered taste, blurred vision, burning or stinging sensations, corneal infiltrates, corneal staining, dermatitis, discomfort, dry eyes, foreign body sensation, congestion, keratitis, itching, rhinitis, sinusitis, and tearing were less common (usually below 5%, and often even lower).
Symptoms typically improve gradually after discontinuation; if discomfort persists, please consult an ophthalmologist.
3.
This medication is indicated for the temporary relief of symptoms and signs of allergic conjunctivitis.
If you experience blurred vision after using this medication, please seek prompt evaluation from an ophthalmologist to determine if it is due to the medication or other factors.
4.
As in question 3, please seek prompt evaluation from an ophthalmologist to determine if it is due to the medication or other factors.
5.
Precautions for this medication are as follows: (1) If symptoms do not improve or worsen within a few days, please inform your physician.
(2) Always follow your physician's instructions; do not adjust the dosage or discontinue use on your own.
(3) Patients: To avoid contamination of the bottle and solution, do not let the tip of the bottle touch your eyelid or surrounding areas.
Keep the cap tightly closed when not in use.
If the solution has changed color, do not use it.
If your eyes are red, it is advised not to wear contact lenses.
Emadine should not be used to treat contact lens-related irritation.
The preservative Benzalkonium chloride in Emadine may adhere to soft contact lenses.
Patients who wear contact lenses and do not have red eyes should wait at least 10 minutes after instilling Emadine before reinserting their contact lenses.
I hope this answers your questions, and I wish you good health.

Reply Date: 2019/06/15

More Info


Emedastine Difumarate, commonly known by its brand name Emadine, is an antihistamine eye drop primarily used to treat allergic conjunctivitis. This condition is characterized by symptoms such as itching, redness, and swelling of the conjunctiva, which is the membrane covering the white part of the eye and the inner eyelids. Understanding the properties, potential side effects, and usage recommendations for Emedastine Difumarate is crucial for effective treatment.

1. Steroid Content: Emedastine Difumarate does not contain steroids. This is an important distinction because steroid eye drops, while effective in reducing inflammation, can lead to side effects such as increased intraocular pressure, cataract formation, and potential worsening of infections if used long-term. Emedastine, being a non-steroidal antihistamine, is generally safer for prolonged use in managing allergic symptoms without the risk of these steroid-related complications.

2. Side Effects: The most common side effects associated with Emedastine include headache (reported in about 11% of patients), burning or stinging upon instillation, dry eyes, and transient blurred vision. Other less common side effects may include conjunctival hyperemia (redness), eye discomfort, and allergic reactions. The incidence of these side effects is relatively low, with most occurring in less than 5% of users. Importantly, if any side effects do occur, they are typically reversible upon discontinuation of the medication. If symptoms persist after stopping the medication, it is advisable to consult with an eye care professional.

3. Blurred Vision: If you are experiencing blurred vision in your left eye, it is essential to consult your eye doctor before continuing the use of Emedastine. While this medication is not known to cause significant visual disturbances, individual reactions can vary. The fact that you have undergone a dilated eye exam and no issues were found is reassuring, but any new or worsening symptoms should be evaluated promptly. Your eye doctor may want to investigate other potential causes of your blurred vision, such as refractive errors or other ocular conditions.

4. Impact on Vision: After instilling Emedastine, some patients may experience temporary blurred vision. This is usually short-lived and should resolve quickly. However, if you find that your vision becomes more blurred or if you experience any other concerning symptoms, it is crucial to seek medical advice. Your eye care provider can help determine whether the medication is contributing to your symptoms or if there is another underlying issue that needs to be addressed.

In summary, Emedastine Difumarate is a valuable medication for managing allergic conjunctivitis without the risks associated with steroid use. While side effects are generally mild and reversible, any persistent or new symptoms warrant a discussion with your healthcare provider. Always follow your doctor's instructions regarding the use of eye drops and report any unusual changes in your vision or eye comfort.

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