Concerns About Concurrent Use of Kankin and Diltiazem for Arrhythmia - Cardiology

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Kanken medication issues?


Hello, Director: I have an issue with arrhythmia, and my doctor has prescribed Concor 1.25 mg to be taken once in the morning and once in the evening, along with Amlodipine 240 mg in the morning.
I have researched online and it seems that using Concor and Amlodipine (a calcium channel blocker) together may have adverse effects on the heart.
Could you please clarify this for me? Thank you!

Wang Zhenyu, 60~69 year old female. Ask Date: 2019/06/20

Dr. Huang Yinghe reply Cardiology


Hello: Bisoprolol and Verapamil are commonly used medications for controlling arrhythmias.
They work by reducing heart rate and decreasing the occurrence of premature beats, which can help alleviate symptoms such as palpitations and chest discomfort.
Depending on individual responses to the medication, physicians typically start with a single agent.
If the desired effect is not achieved, it is possible to use two or more medications concurrently.
However, combining these two drugs may lead to the side effect of bradycardia.
When monitoring blood pressure at home, it is advisable to pay attention to the heart rate; a rate of 50-60 beats per minute is generally acceptable.
If the heart rate frequently falls below 50, please discuss with your physician whether a medication adjustment is necessary.

Reply Date: 2019/06/20

More Info


When considering the concurrent use of Kankin (which contains the active ingredient ketotifen) and Diltiazem (a calcium channel blocker), it is essential to understand the pharmacological properties of both medications and their potential interactions.
Kankin is primarily used as an antihistamine and is often prescribed for allergic conditions, including asthma and other respiratory issues. It works by blocking histamine receptors, which can help alleviate symptoms such as wheezing and shortness of breath. However, one of the side effects of Kankin can include sedation and respiratory depression, which may be concerning for patients with existing respiratory conditions.

On the other hand, Diltiazem is a calcium channel blocker that is commonly used to manage hypertension and certain types of arrhythmias. It works by relaxing the blood vessels and reducing the heart's workload, which can help control heart rate and rhythm. Diltiazem is effective in treating conditions like atrial fibrillation and angina, but it can also lead to side effects such as bradycardia (slow heart rate) and hypotension (low blood pressure).

The concern with using Kankin and Diltiazem together arises from their potential additive effects on the cardiovascular and respiratory systems. Both medications can influence heart rate and rhythm, and when combined, there is a risk of exacerbating bradycardia or other arrhythmias. Additionally, Kankin's sedative effects may compound the hypotensive effects of Diltiazem, leading to increased dizziness or fainting, particularly in older adults or those with pre-existing conditions.

It is crucial to monitor for any signs of adverse effects when these medications are used together. Patients should be vigilant for symptoms such as excessive fatigue, dizziness, or any unusual changes in heart rhythm. If any of these symptoms occur, it is advisable to contact a healthcare provider immediately.

Furthermore, it is essential to have open communication with your healthcare provider regarding all medications you are taking, including over-the-counter drugs and supplements. Your doctor can assess the risks and benefits of continuing this combination therapy based on your specific health profile, including your history of arrhythmias and any other underlying conditions.

In conclusion, while Kankin and Diltiazem can be used concurrently, it is vital to approach this combination with caution. Regular follow-ups with your healthcare provider are necessary to ensure that your treatment plan is safe and effective. If you have concerns about the potential interactions or side effects, do not hesitate to discuss them with your physician, who can provide personalized advice and may consider alternative therapies if necessary.

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