Drug Interactions: Impact on Birth Control Effectiveness - Obstetrics and Gynecology

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Drug interactions


Hello, doctor.
I have been taking Mestranol for four months now.
My last menstrual period started on June 1, and I expect my next one to begin in five days.
I had unprotected intercourse with my boyfriend both this afternoon and last week, but he withdrew before ejaculation.
I have not missed any doses of the medication; I take it around the same time every day.
However, I have a lower back strain and will be going to the clinic tonight for an anti-inflammatory injection, which may possibly be a steroid, but I'm not sure; I just know it's for inflammation.
Will this affect the effectiveness of my birth control pill? Wednesday will be the first day of my seven-day break.
Also, if I have a urinary tract infection and take antibiotics, will that affect the effectiveness of the birth control pill?

Xiao Yun, 10~19 year old female. Ask Date: 2019/06/24

Dr. Huang Jianzhong reply Obstetrics and Gynecology


I have been taking Medroxyprogesterone for four months.
My last menstrual period started on June 1, and I expect my next one to begin in five days.
I had unprotected intercourse with my boyfriend both this afternoon and last week, but he withdrew before ejaculation.
I have not missed any doses of the medication, taking it around the same time every day.
However, I have a back strain and will be going to the clinic tonight for an anti-inflammatory injection, which may be a steroid, but I'm not sure; I just know it's for inflammation.
Will this affect the effectiveness of my birth control? Wednesday will be the first day of my seven-day break from the medication.

Answer: No, it will not affect the effectiveness of the birth control.

Additionally, if I have urethritis and take antibiotics, will that affect the effectiveness of the birth control?
Answer: No, it will not affect the effectiveness of the birth control.

Reply Date: 2019/06/24

More Info


When it comes to understanding drug interactions and their potential impact on the effectiveness of birth control methods, it is essential to consider the specific medications involved and their mechanisms of action. In your case, you are currently taking a birth control pill (美適儂) and are concerned about the potential effects of anti-inflammatory medication, possibly a steroid, and antibiotics for a urinary tract infection (UTI).

Firstly, it is important to note that most common oral contraceptives, including 美適儂, are generally not significantly affected by anti-inflammatory medications or steroids. These medications do not typically interfere with the hormonal mechanisms of birth control pills. Therefore, if you are prescribed an anti-inflammatory injection, it is unlikely to diminish the effectiveness of your birth control method. However, it is always prudent to inform your healthcare provider about all medications you are taking, including birth control, to ensure they can provide the best advice tailored to your situation.

On the other hand, the interaction between antibiotics and birth control pills is a more nuanced topic. While many antibiotics do not affect the efficacy of oral contraceptives, there are specific antibiotics that have been shown to potentially reduce their effectiveness. For instance, rifampicin and some other antibiotics used for tuberculosis treatment can induce liver enzymes that metabolize contraceptive hormones, leading to decreased effectiveness. However, most commonly prescribed antibiotics, such as amoxicillin or ciprofloxacin, do not have this effect.

In your case, if you are prescribed antibiotics for a UTI, it is essential to check which specific antibiotic you will be taking. If it is one of the antibiotics known to interact with birth control pills, it is advisable to use additional contraceptive methods (such as condoms) for at least seven days while on the antibiotic and for seven days after completing the course. This precaution helps ensure that you maintain effective contraception during this period.

Additionally, it is crucial to consider the timing of your birth control pill intake. Consistency in taking your pill at the same time every day is vital for maintaining its effectiveness. Since you mentioned that you have been diligent in taking your pill without missing any doses, this consistency works in your favor.

Lastly, if you have any concerns about the medications you are taking or their interactions, it is always best to consult with your healthcare provider or pharmacist. They can provide personalized advice based on your medical history and the specific medications involved.
In summary, while anti-inflammatory medications are unlikely to affect your birth control pill's effectiveness, it is essential to be cautious with antibiotics. Always verify the specific antibiotic prescribed and consider using additional contraceptive methods if necessary. Maintaining open communication with your healthcare provider about all medications you are taking will help ensure your contraceptive method remains effective.

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