Alternative Treatments for Chlamydia When Doxycycline Fails - Urology

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Issues with treatment medications for Mycobacterium avium complex (MAC) infection?


Hello doctor, I have researched online and found that most treatments involve doxycycline.
However, my health check report indicated that I have developed resistance to doxycycline.
Can the following medications, taken for seven days, effectively treat Chlamydia? Curam F.C.
1000 mg/tab and Amoxicillin 875 mg, Clavulanate 125 mg.

KenJ, 30~39 year old female. Ask Date: 2019/07/04

Dr. Cai Zhuorong reply Urology


Please note that it is bacteria, not humans, that develop drug resistance.
Health check-ups cannot provide you with information regarding drug resistance.
According to CDC guidelines, the treatment for Chlamydia includes: Azithromycin 1 g orally in a single dose OR Doxycycline 100 mg orally twice a day for 7 days.
Alternative regimens include Erythromycin base 500 mg orally four times a day for 7 days OR Erythromycin ethylsuccinate 800 mg orally four times a day for 7 days OR Levofloxacin 500 mg orally once daily for 7 days OR Ofloxacin 300 mg orally twice a day for 7 days.
All of these are prescription medications, and it is recommended that you visit a urology clinic.

Reply Date: 2019/07/04

More Info


When it comes to treating Chlamydia, Doxycycline is often the first-line treatment due to its effectiveness. However, if a patient has developed resistance to Doxycycline, alternative treatments are necessary. In your case, you mentioned that you have resistance to Doxycycline, which is an important factor to consider when selecting an alternative treatment.

The medications you listed, Curam F.C. (which contains Amoxicillin and Clavulanate) and Amoxicillin 875 mg with Clavulanate 125 mg, are not typically the first choice for treating Chlamydia. While Amoxicillin can be effective against some bacterial infections, it is not the preferred treatment for Chlamydia. The standard alternative treatments for Chlamydia, especially in cases of Doxycycline resistance, include Azithromycin and Levofloxacin.

1. Azithromycin: This is often given as a single dose of 1 gram orally. It is effective against Chlamydia and is a good alternative for those who cannot take Doxycycline.

2. Levofloxacin: This is another alternative that can be used, typically dosed at 500 mg once daily for 7 days. It is a fluoroquinolone antibiotic that can effectively treat Chlamydia.

Regarding your specific question about the effectiveness of Curam F.C. or Amoxicillin with Clavulanate for treating Chlamydia, these medications are not typically recommended for this infection. While they may have some antibacterial properties, they do not have the same efficacy against Chlamydia as Azithromycin or Levofloxacin.

It is crucial to consult with your healthcare provider about your resistance to Doxycycline and discuss the best alternative treatment options. They may also consider performing sensitivity testing to determine which antibiotics are effective against your specific strain of Chlamydia.
In addition to medication, it is essential to inform any sexual partners about the infection so they can also be tested and treated if necessary. This helps prevent reinfection and further spread of the disease.
Lastly, if you have any concerns about side effects or interactions with other medications you may be taking, be sure to discuss these with your healthcare provider. They can provide guidance tailored to your specific health needs and circumstances.
In summary, while Curam F.C. and Amoxicillin with Clavulanate are not the standard treatments for Chlamydia, alternatives like Azithromycin or Levofloxacin should be considered. Always consult with your healthcare provider for the most appropriate treatment plan based on your individual situation.

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