HPV Infection Risks, Testing, and Treatment Options - Urology

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What are the risks of HPV (human papillomavirus) infection, the screening methods, and the treatment options when there are no obvious lesions?


1.
Risk assessment for HPV infection: Online sources indicate that the transmission routes for HPV include sexual contact, vertical transmission from mother to child, and environmental contact, which also carries a risk of infection.
Therefore, I would like to ask Dr.
Duckbill for a risk assessment regarding the following scenario: a female worker and I engaged in mutual masturbation without any physical contact or bodily fluid exchange.
Afterward, the female partner did not wash her hands and used a tissue to wipe my glans.
What is the risk assessment for this behavior?
2.
In the above situation, if there are concerns about potential HPV infection, is it possible to conduct tests to determine the presence of HPV without any obvious lesions? What is the window period for such testing?
3.
Continuing from the above situation, if HPV types 6 or 11 are detected without any lesions present, are there any treatment options available? Alternatively, can a vaccine be administered to enhance immunity in the absence of symptoms? Thank you, Dr.
Duckbill, for your response.

Weiwei, 30~39 year old female. Ask Date: 2019/07/12

Dr. Du Shixi reply Urology


1.
The description of risky behaviors is as follows:
- No risk: masturbation
- Low risk: mutual masturbation, light kissing, mutual rubbing, sexual activity with condom
- Moderate risk: deep kissing, oral sex, withdrawal method
- High risk: unprotected sexual activity, resulting in wounds or bleeding, as per your description, poses no risk.
2.
The incubation period for HPV is 7 to 14 days, but it typically takes an average of 3 months for symptoms to appear at the infection site, although it can range from 3 weeks to several years.
3.
Vaccination can prevent infection before symptoms develop, but there are some reported side effects of the vaccine in other countries.
You can research this yourself; currently, there is no definitive treatment for asymptomatic infections.

The following are the indications for the 9-valent vaccine:
GARDASIL 9 is a vaccine suitable for girls and women aged 9 to 26, used to prevent lesions caused by human papillomavirus (HPV), including:
- Cervical cancer caused by HPV types 16, 18, 31, 33, 45, 52, and 58
- Genital warts (condylomata acuminata) caused by HPV types 6 and 11
- Grade 1 cervical intraepithelial neoplasia (CIN 1), Grade 2 and 3 cervical intraepithelial neoplasia (CIN 2/3) caused by HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58
- Adenocarcinoma in situ (AIS) of the cervix, Grade 2 and 3 vulvar intraepithelial neoplasia (VIN 2/3), and Grade 2 and 3 vaginal intraepithelial neoplasia (VaIN 2/3) caused by HPV types 6, 11, 16, and 18
For boys and men:
GARDASIL 9 is suitable for boys and men aged 9 to 26, to prevent genital warts (condylomata acuminata) caused by HPV types 6 and 11.

Reply Date: 2019/07/12

More Info


Understanding HPV (Human Papillomavirus) infection risks, testing methods, and treatment options is crucial for maintaining sexual health. Let's break down the questions and provide a comprehensive overview.


1. Risk Assessment of HPV Infection
HPV is primarily transmitted through direct skin-to-skin contact during sexual activities, including vaginal, anal, and oral sex. The risk of transmission through non-sexual contact, such as touching contaminated surfaces, is considered very low. In the scenario described, where both individuals are engaging in mutual masturbation without direct contact or exchange of bodily fluids, the risk of HPV transmission is minimal. However, if one partner has HPV on their hands and then touches the other partner's genital area, there is a theoretical risk, albeit low, especially if there are no visible lesions or cuts.


2. Testing for HPV Infection
If there are concerns about potential HPV infection, testing can be performed even in the absence of visible symptoms or lesions. The "window period" for HPV detection can vary; typically, HPV can be detected within 7 to 14 days post-exposure, but it may take several weeks to months for the virus to become detectable, depending on the individual's immune response. In many cases, HPV can remain dormant for years before causing any symptoms or abnormalities.


3. Treatment Options for HPV Types 6 and 11
HPV types 6 and 11 are classified as low-risk types, primarily associated with genital warts rather than cancer. If an individual tests positive for these types but shows no clinical signs or lesions, there is generally no need for treatment. The body’s immune system can often clear the virus on its own over time.
Vaccination is an effective preventive measure against HPV. The HPV vaccine (such as Gardasil 9) can protect against multiple strains of HPV, including high-risk types that can lead to cancer. If someone is already infected with certain HPV types, the vaccine will not treat existing infections but can provide protection against other types not yet contracted. It is advisable to consult with a healthcare provider regarding the timing of vaccination, especially if there is a known HPV infection.


Additional Considerations
- Immune Response: It is true that a significant percentage of individuals (approximately 60-75%) can clear HPV infections naturally due to their immune response. This means that the virus may no longer be present in the body, or its levels may be reduced to a point where it is not infectious or pathogenic.


- Persistent Infection: Persistent infection refers to the continued presence of high-risk HPV types in the body, which can lead to cellular changes and potentially progress to conditions such as cervical intraepithelial neoplasia (CIN) or cancer. Regular monitoring and follow-up testing are essential for individuals with persistent infections.

- Follow-Up Testing: For individuals who have tested positive for HPV, follow-up testing is crucial. It is generally recommended to have a Pap smear and HPV test every 3 to 5 years, depending on age and health history. If there are abnormal results, more frequent monitoring may be necessary.

In conclusion, understanding HPV risks, testing, and treatment options is vital for sexual health. Engaging in safe sexual practices, regular screenings, and vaccinations can significantly reduce the risk of HPV-related complications. If there are any concerns or symptoms, it is always best to consult with a healthcare professional for personalized advice and management.

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