Post-Orchiectomy Hormone Replacement: Safety and Options Explained

Q: Post-Orchiectomy Hormone Replacement: Safety and Options Explained

Hello： Regarding male hormones, I personally only recommend their use for individuals who have low levels as indicated by blood tests, due to potential side effects. <br>The so-called "natural" male hormones refer to the raw materials of human male hormones, which, when used, are

Post-orchiectomy supplementation?

Hello doctor, my father had one of his testicles removed due to a tumor six months ago.
Recently, he often mentions wanting to take male hormones, but I have seen that doctors say taking male hormones can increase the risk of cancer.
He mentioned that his doctor said he could take "natural" male hormones.
Does that refer to capsule forms, or is it just natural food sources? Or would it be sufficient to take regular zinc supplements?

Mia, 20~29 year old female. Ask Date: 2019/08/02

Dr. Du Shixi reply Urology

Hello: Regarding male hormones, I personally only recommend their use for individuals who have low levels as indicated by blood tests, due to potential side effects.
The so-called "natural" male hormones refer to the raw materials of human male hormones, which, when used, are utilized by the body and converted into male hormones, making them relatively safer.
If your father has normal blood test results, he should focus on dietary considerations, which can be researched online, and increase his intake accordingly without the need for specific medications.
Wishing you good health.

Reply Date: 2019/08/02

More Info

Post-orchiectomy hormone replacement therapy (HRT) is a significant topic, especially for individuals who have undergone orchiectomy due to conditions such as testicular cancer or other medical issues. After the removal of one or both testicles, the body experiences a decrease in testosterone production, which can lead to various physical and psychological symptoms, including fatigue, decreased libido, mood changes, and loss of muscle mass. Therefore, hormone replacement therapy may be considered to alleviate these symptoms and improve the quality of life.

When it comes to testosterone replacement therapy, there are several options available, including synthetic testosterone and bioidentical hormones. Your father’s mention of "natural" testosterone could refer to bioidentical hormones, which are chemically identical to the hormones produced by the human body. These can be administered in various forms, including gels, patches, injections, and capsules. It is essential to clarify with his healthcare provider what is meant by "natural" testosterone, as this term can sometimes be misleading.

Concerns about testosterone therapy and cancer risk are valid and have been the subject of extensive research. Some studies have suggested a potential link between testosterone therapy and an increased risk of prostate cancer, particularly in men who already have a predisposition to this condition. However, the evidence is not conclusive, and many healthcare providers believe that testosterone therapy can be safely administered under careful monitoring. It is crucial for your father to discuss his specific health history and concerns with his healthcare provider, who can provide personalized advice based on the latest research and guidelines.

Regarding the use of zinc supplements, while zinc is an essential mineral that plays a role in testosterone production, it is not a substitute for hormone replacement therapy. Zinc supplementation may help support overall health and hormonal balance, but it is unlikely to provide the same benefits as direct testosterone replacement. If your father is considering zinc or any other supplements, he should consult with his doctor to ensure they are appropriate for his situation and won't interfere with any other treatments he may be receiving.

In summary, post-orchiectomy hormone replacement therapy can be a beneficial option for managing symptoms related to low testosterone levels. It is essential for your father to have an open and thorough discussion with his healthcare provider about the risks and benefits of testosterone therapy, the types of testosterone available, and any concerns he may have regarding cancer risk. This collaborative approach will help ensure that he receives the most appropriate and effective treatment for his needs.

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