Nasopharyngeal Biopsy: Accuracy and Techniques Explained - Otolaryngology

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Nasopharyngeal biopsy issues?


Hello, doctor.
I have been experiencing slight pain when swallowing saliva on the right side of my throat.
After visiting an otolaryngologist, it was found that the nasopharynx on the right side is somewhat swollen (but the doctor mentioned that the swelling is in the middle of the nasopharynx, as nasopharyngeal carcinoma typically occurs on the sides).
The left nostril appears normal, while the right nostril shows swelling more towards the middle right.
I recently underwent a nasopharyngeal biopsy, and the results indicated benign adenoid tissue.
During the biopsy, I felt that the surgeon was taking tissue samples and performing hemostasis through the left nostril, but I saw in the images that the swelling was visible in the nasopharynx through the right nostril.
I would like to ask if sampling from different nostrils is accurate, or if the nasopharyngeal area is interconnected so that sampling can be done from either side? However, the hemostasis performed through the left nostril has left me quite confused.

A Dou, 30~39 year old female. Ask Date: 2019/10/01

Dr. Ji Zhaoyun reply Otolaryngology


Hello, the nasopharynx is interconnected on both sides, so sampling can be done from either side.
Sometimes, due to the size of the nasal cavity, it may not be possible to insert both the endoscope and the biopsy forceps on one side simultaneously, and sampling may need to be done from the opposite side.
However, if you have any questions, it is still recommended to consult the original surgeon for the best advice.

Reply Date: 2019/10/01

More Info


When it comes to understanding nasopharyngeal biopsies, particularly in the context of your recent experience, it’s important to clarify a few key points regarding the anatomy, techniques, and accuracy of such procedures.


Anatomy and Access
The nasopharynx is a region located behind the nose and above the soft palate. It is a space that connects the nasal cavity to the oropharynx and is bordered by various structures, including the adenoids and the Eustachian tubes. Importantly, the nasopharynx is not strictly divided into left and right compartments; rather, it is a continuous space. This means that accessing the nasopharynx from either the left or right nostril can allow for visualization and sampling of tissue from the same area.


Biopsy Techniques
In your case, the biopsy was performed through the left nostril, while the area of concern was noted in the right side of the nasopharynx. This is a common practice, as the endoscopic tools used in these procedures are designed to navigate through the nasal passages and reach the nasopharyngeal area effectively, regardless of the entry point. The physician can maneuver the endoscope to visualize and sample tissue from the desired location, even if the entry point is not directly aligned with the area of interest.


Accuracy of Sampling
The accuracy of a biopsy depends on several factors, including the technique used, the experience of the physician, and the nature of the lesion being sampled. In your case, the biopsy results indicated benign adenoid tissue, which suggests that the sampling was performed correctly. However, it is essential to note that if there were any concerns about malignancy or if the lesion had atypical features, a repeat biopsy or further imaging might be warranted to ensure that the diagnosis is accurate.


Considerations for Future Procedures
If there is any uncertainty about the biopsy results or if symptoms persist, it is advisable to follow up with your ENT specialist. They may recommend additional imaging studies, such as a CT scan, to further evaluate the nasopharynx or possibly a repeat biopsy if there are still concerns about the nature of the lesion.


Conclusion
In summary, accessing the nasopharynx through either nostril is a standard practice, and the continuous nature of the nasopharyngeal space allows for effective sampling regardless of the entry point. Your biopsy results indicating benign tissue are reassuring, but ongoing communication with your healthcare provider is crucial for monitoring your symptoms and ensuring appropriate management. If you have further questions or concerns, do not hesitate to reach out to your ENT specialist for clarification and guidance tailored to your specific situation.

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