One-Sided Throat Pain: Is It Tonsil Cancer? - Otolaryngology

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Sore throat on one side?


I have been experiencing a sore throat since early September, with more pain on the right side.
Swallowing and eating are painful, but drinking water is somewhat manageable.
I have had a total thyroidectomy, so when I palpate my neck, I notice an enlarged lymph node (below the ear) and some tenderness in the neck area.
I visited a clinic where the doctor confirmed that the right lymph node is indeed enlarged and that my tonsils are slightly inflamed.
After taking medication for nearly two weeks, I felt some improvement, but four days ago, the pain returned, primarily on the right side, with occasional pain on the left.
Eating is more painful than drinking water.
I then consulted an otolaryngologist, who stated that the right tonsil is slightly inflamed and prescribed anti-inflammatory medication, antibiotics (Keflex 500 mg), stomach medication, and a muscle relaxant.

Yesterday, I noticed swelling in my gums (in the area of the upper right canine where I have a crown).
The dentist indicated that this is likely unrelated to the tonsils and suggested that the root of the crown might be cracked.
Today, I discovered that I also have pain near the lower left wisdom tooth and the upper right wisdom tooth, and there is soreness in the area where I bite down when eating or opening my mouth (I’m not sure if this is due to repeatedly using a flashlight to examine my mouth or if it’s related to my profession as a teacher).

I have been researching online and found information about unilateral tonsillar enlargement and pain in the masseter muscle, which can lead to difficulty opening the mouth, raising concerns about tonsil cancer.
Given my history of stage 0 thyroid cancer (which has been removed), I am very anxious and would like to ask the doctor if this could be tonsil cancer.
Additionally, how enlarged does a tonsil need to be to be considered significant in the context of tonsil cancer?

Chen Afu, 40~49 year old female. Ask Date: 2019/10/05

Dr. Zheng Jueyi reply Otolaryngology


Hello, the tonsils may have a congenital size difference on both sides.
An unequal size can serve as a reminder to check for abnormalities in the larger tonsil, such as persistent ulcers or unexplained tumors.
If there are concerns, the physician may recommend a biopsy or surgery to confirm any abnormalities.
If you are worried, it is advisable to seek evaluation from an otolaryngologist.
Wishing you safety and health.
Sincerely, Dr.
Cheng Jue-Yi, Director of the Department of Otolaryngology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2019/10/05

More Info


Understanding one-sided throat pain can be quite concerning, especially for someone with a history of thyroid cancer. Your symptoms, including persistent pain on the right side of your throat, difficulty swallowing, and the presence of a swollen lymph node, warrant careful evaluation. While it is understandable to worry about the possibility of tonsil cancer, it is essential to consider various factors and potential diagnoses.

Firstly, the inflammation of the tonsils (tonsillitis) is a common cause of unilateral throat pain. This condition can lead to swelling and discomfort, particularly when swallowing. The fact that you have been prescribed antibiotics suggests that your healthcare provider is considering an infectious cause, which is often treatable. If the swelling and pain improve with medication but then recur, it may indicate a chronic issue or a need for further investigation.

The presence of an enlarged lymph node in your neck is also significant. Lymph nodes can become enlarged due to infections, inflammatory conditions, or malignancies. In your case, the lymph node enlargement could be a response to the tonsillitis or another infection. However, given your history of thyroid cancer, it is prudent to monitor this closely.

Regarding your concerns about tonsil cancer, it is important to note that while unilateral tonsil enlargement can be a symptom of malignancy, it is not the only possibility. Tonsil cancer typically presents with other symptoms, such as persistent sore throat, difficulty swallowing, ear pain, or a noticeable mass in the throat. The degree of swelling that is considered concerning can vary, but any significant change in size or consistency of the tonsil, especially if accompanied by other alarming symptoms, should be evaluated by a specialist.

In your case, since you have experienced a recurrence of pain and swelling, it would be advisable to seek a thorough evaluation from an otolaryngologist (ear, nose, and throat specialist). They may recommend imaging studies, such as a CT scan or MRI, to assess the tonsils and surrounding structures more comprehensively. A biopsy may also be necessary if there is any suspicion of malignancy.

Additionally, your dental issues, including swelling around your gums and potential problems with your dental work, could be contributing to your discomfort. It is essential to address these concerns with your dentist, as dental infections can also lead to referred pain in the throat and jaw.

In summary, while your symptoms could potentially indicate tonsil cancer, they are more likely related to an infectious or inflammatory process, especially given the recent history of tonsillitis. However, due to your medical history, it is crucial to remain vigilant and seek further evaluation to rule out any serious conditions. Regular follow-ups with your healthcare providers and open communication about your symptoms will be key in managing your health effectively.

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