Hepatitis B Recovery: Why Ongoing Monitoring is Essential - Gastroenterology and Hepatology

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Hepatitis B testing issues?


Doctor, I previously had the following test results: HBsAg(-), HBeAg(-), HBcIgG(+).
Today, I followed up on my hepatitis B and paid out of pocket for the HBsAb antibody test, which came back positive (399).
Other tests for AFP, ALT, and AST were also normal.
I initially thought I wouldn't need to follow up anymore, but the doctor said, "Theoretically, your hepatitis B has resolved, and you have antibodies, which means you have lifelong immunity.
However, upon ultrasound examination of your liver, it appears somewhat rough, possibly due to past hepatitis B inflammation, so I recommend continuing to monitor every six months." It feels like a false alarm; is such caution really necessary?

Zhang Yingtong, 60~69 year old female. Ask Date: 2019/11/12

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: HBsAg(-) HBsAb(+) HBcIgG(+) indicates a past infection with hepatitis B, and the individual has now cleared the infection and has antibodies to protect against hepatitis B.
However, if someone was a long-term hepatitis B carrier, regardless of whether they have achieved functional cure through antiviral medication or interferon treatment, if the duration of infection has been prolonged leading to significant liver fibrosis, especially in cases of severe liver fibrosis progressing to cirrhosis, there remains a risk of hepatocellular carcinoma despite functional cure of hepatitis B.
Therefore, it is still recommended to undergo ultrasound monitoring.
Wishing you peace and health! Sincerely, Dr.
Ming-Hui Lin, Attending Physician, Gastroenterology Department, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2019/11/12

More Info


Understanding Hepatitis B Recovery: Why Ongoing Monitoring is Essential
Hepatitis B is a viral infection that can lead to chronic liver disease, cirrhosis, and even liver cancer. The management of Hepatitis B involves understanding various serological markers and the implications of liver health over time. Your recent test results indicate that you have cleared the Hepatitis B virus (HBV) infection, as evidenced by the presence of HBsAb (antibody to Hepatitis B surface antigen) and the absence of HBsAg (Hepatitis B surface antigen). This suggests that you have developed immunity against the virus, which is a positive outcome.

However, your physician's recommendation for ongoing monitoring every six months is prudent and based on several important considerations. First, while you may have cleared the virus and developed antibodies, the liver may still exhibit signs of past inflammation or damage. The ultrasound indicating a rough texture of the liver suggests that there may have been significant liver inflammation in the past, which can lead to fibrosis or even cirrhosis. These conditions increase the risk of developing hepatocellular carcinoma (liver cancer) later in life, even if the virus is no longer active.

The presence of HBcIgG indicates a past infection, and while you have achieved functional cure (as indicated by HBsAg negative and HBsAb positive), the history of inflammation can have long-term implications. Chronic liver conditions can remain asymptomatic for years, and regular monitoring is essential to detect any potential complications early. This includes monitoring liver function tests (ALT, AST), imaging studies (ultrasound), and alpha-fetoprotein (AFP) levels, which can serve as a tumor marker for liver cancer.

Moreover, the liver has a remarkable capacity for regeneration, but it is also susceptible to damage from various factors, including alcohol consumption, obesity, and other viral infections. If you were to experience a decline in your immune function or exposure to other hepatotoxic agents, there is a risk that liver disease could re-emerge. Therefore, maintaining a proactive approach with regular follow-ups is crucial.

In summary, while your current serological markers indicate that you are in a good position regarding Hepatitis B, the history of liver inflammation necessitates ongoing monitoring. This is not merely a precaution but a vital part of ensuring your long-term liver health. Regular check-ups can help catch any potential issues early, allowing for timely intervention if necessary. Your physician's recommendation is not an overreaction but rather a responsible approach to managing your health in light of your medical history. It is always better to err on the side of caution when it comes to liver health, given the serious consequences that can arise from undetected liver disease.

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