Consultation on Urology Medication and Treatment Concerns - Urology

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Follow-up consultation inquiries?


Hello, Doctor.
I would like to report the results of my urodynamic study from Saturday.
First of all, it was quite an uncomfortable experience.
During the bladder filling phase, the doctor reviewed the results with me on the same day and mentioned that I have bladder overactivity, as indicated by the urodynamic graph, and that my bladder capacity is only 200 cc.
I need to undergo further training.
The doctor prescribed medication for a week, specifically Oxbutynin Extended-release 5 mg.
Additionally, he prescribed Tofranil S.C.
25 mg, stating that it was for my poor sleep quality and advised me to take it before bed.
However, I informed the doctor that I am already receiving treatment for insomnia from a psychiatrist, who has prescribed Bromazepam 3 mg and Fute 0.5 mg.
I asked the doctor if there would be any overlap in medications, but he did not respond.
In fact, I have not taken any of the medications prescribed by the psychiatrist due to concerns about dependency; I only take half a tablet.

After my appointment, I went to the pharmacy to pick up my prescriptions and relayed my situation to the pharmacist.
The pharmacist recommended that I take the Oxbutynin Extended-release 5 mg but advised against taking the Tofranil S.C.
25 mg, suggesting that I continue with the original medications prescribed by my psychiatrist.
He also mentioned that I should take the Fute 0.5 mg earlier, after meals, rather than before bed, as the Tofranil S.C.
25 mg has similar components to what my psychiatrist prescribed, and taking both might affect my concentration during the day.
I am currently following the pharmacist's advice, but I would like to know if this is the right approach.
Thank you for your guidance.

Additionally, I am not sure if it was due to anxiety, but after my follow-up appointment last Wednesday, I suddenly noticed that the feeling of heaviness in my lower abdomen has disappeared, and my urine output has returned to 200-250 cc, with a minimum of 125 cc.
I have another follow-up appointment next week!

Er Mao, 50~59 year old female. Ask Date: 2019/11/17

Dr. Du Shixi reply Urology


Hello: Oxbutynin can reduce the frequency of urination and increase urine volume.
Tofranil is commonly used to treat nocturnal enuresis and is safe for children; I don't recall any side effects.
Currently, you are on medication and waiting for a follow-up appointment.
You can keep a voiding diary for the physician's reference, and it's important to continue monitoring your lifestyle.
Wishing you good health.

Reply Date: 2019/11/17

More Info


Hello! Thank you for sharing your experience and concerns regarding your recent urology consultation and medication regimen. It's understandable to feel overwhelmed when navigating multiple medications and their potential interactions, especially when dealing with issues related to bladder function and sleep disturbances.

From what you've described, it seems that your urologist has diagnosed you with bladder hyperactivity, which is often characterized by a frequent urge to urinate and can be accompanied by discomfort. The medication Oxbutynin (Oxbu Extended-release) is commonly prescribed for this condition as it helps to relax the bladder muscle, thereby reducing urgency and frequency of urination. The dosage of 5 mg extended-release is a standard starting point, and it may take some time to see the full benefits of the medication.

Regarding the second medication, Tofranil (Imipramine) is a tricyclic antidepressant that is sometimes used off-label to treat bladder issues due to its ability to help relax the bladder and improve sleep quality. However, it can also have sedative effects, which may impact your alertness during the day. It's important to note that combining medications can sometimes lead to overlapping effects, particularly with sedatives, which could exacerbate drowsiness or impair cognitive function.

You mentioned that you are also taking Bromazepam and Fute (Fluoxetine) prescribed by your psychiatrist. Bromazepam is a benzodiazepine that can cause sedation and has a potential for dependence, while Fluoxetine is an SSRI that is primarily used to treat depression and anxiety. The concern raised by your pharmacist about the potential for overlapping effects between Tofranil and your current medications is valid. Taking both could indeed lead to increased sedation and affect your ability to concentrate during the day.

Given your situation, it might be beneficial to have a more in-depth discussion with both your urologist and psychiatrist about your medication regimen. Here are a few recommendations:
1. Medication Review: Request a comprehensive review of all your medications from both your urologist and psychiatrist. This will help ensure that there are no harmful interactions and that your treatment plan is optimized for both your bladder issues and sleep concerns.

2. Monitor Symptoms: Keep track of your symptoms, including any changes in urinary frequency, urgency, and sleep quality. This information will be valuable for your healthcare providers to adjust your medications as needed.

3. Gradual Adjustments: If you and your healthcare providers decide to make changes to your medication, it’s often best to do so gradually. This allows you to monitor how your body responds to each change.

4. Lifestyle Modifications: In addition to medication, consider lifestyle changes that may help with both bladder health and sleep quality. This could include bladder training exercises, dietary adjustments (such as reducing caffeine and alcohol), and establishing a regular sleep routine.

5. Follow-Up Appointments: Since you have a follow-up appointment next week, prepare any questions or concerns you have regarding your medications and symptoms. This will help ensure that you get the most out of your visit.

It's great to hear that you've noticed some improvement in your symptoms, such as a decrease in the feeling of heaviness in your abdomen and an increase in urine volume. These changes are encouraging and suggest that your treatment may be having a positive effect.

In summary, while it’s important to follow your healthcare provider's recommendations, it's equally important to communicate openly about your concerns and experiences with your medications. This collaborative approach will help ensure that you receive the best possible care tailored to your needs. If you have any further questions or need clarification, don’t hesitate to reach out to your healthcare team. Wishing you the best in your treatment journey!

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