Missed Period After Stopping Medication: Possible Causes Explained - Obstetrics and Gynecology

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Menstrual delay after discontinuing medication?


Dear Dr.
Huang, my girlfriend has been taking Medroxyprogesterone for menstrual regulation for some time, and she wants to stop it to see what happens.
However, her period was expected to start 8 days ago, and it still hasn't arrived.
She also took a pregnancy test two days ago, which came back negative.
She has been taking Medroxyprogesterone for over six months.
What could be the reason for this?

Xiao, 20~29 year old female. Ask Date: 2019/12/16

Dr. Huang Jianzhong reply Obstetrics and Gynecology


My girlfriend was taking Medroxyprogesterone for menstrual regulation, and she recently decided to stop to see what would happen.
She was originally supposed to get her period about 8 days ago, but it still hasn't arrived.
She also took a pregnancy test two days ago, which came back negative.
She has been taking Medroxyprogesterone for over six months.
What could be the reason for this? Answer: Delayed ovulation.

Reply Date: 2019/12/16

More Info


When a person stops taking medication, especially hormonal treatments like the one your girlfriend was using (美適儂, which is likely a form of hormonal contraceptive), it can lead to various changes in the menstrual cycle. The absence of a period after discontinuing such medication is not uncommon and can be attributed to several factors.

Firstly, hormonal contraceptives work by regulating the hormones that control the menstrual cycle. When these medications are stopped, the body may take some time to readjust and resume its natural hormonal balance. This adjustment period can lead to missed periods or irregular cycles, which is often referred to as "post-pill amenorrhea." It is important to note that this can happen even if the individual has been taking the medication consistently and for an extended period, such as six months in your girlfriend's case.

Secondly, stress and lifestyle changes can also impact menstrual cycles. If your girlfriend has experienced any significant changes in her life, such as stress from work, school, or personal relationships, this could contribute to her missed period. Stress can affect the hypothalamus, the part of the brain that regulates hormones, leading to disruptions in the menstrual cycle.

Additionally, weight fluctuations, whether weight gain or loss, can also affect menstrual regularity. If your girlfriend has changed her diet, exercise routine, or overall lifestyle, these factors could influence her cycle as well.

Another consideration is the possibility of pregnancy, even if the pregnancy test came back negative. Home pregnancy tests are generally reliable, but they can sometimes yield false negatives, especially if taken too early. If there is any doubt, it may be worth repeating the test a few days later or consulting a healthcare provider for a blood test, which is more sensitive and can detect pregnancy earlier.

If your girlfriend's period does not return within a few weeks, or if she experiences other concerning symptoms (such as severe pain, unusual discharge, or significant changes in mood or health), it would be advisable for her to consult with a healthcare professional. They can provide a thorough evaluation and determine if any further investigation or treatment is necessary.

In summary, the absence of a period after stopping hormonal medication can be due to the body's adjustment to the hormonal changes, stress, lifestyle factors, or, less commonly, pregnancy. Monitoring the situation and seeking medical advice if the period does not return or if there are other symptoms is the best course of action.

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