Is Wanose Nasal Spray Safe for Pregnant Women at 34 Weeks? - Obstetrics and Gynecology

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Inquiring about medications during pregnancy?


Hello, Doctor.
I am currently 34 weeks pregnant and have been experiencing frequent nosebleeds, so I visited an ENT specialist.
During the examination, they sprayed some medication in my nose, and I noticed the name on the bottle was "wanose." I would like to ask if this medication could affect my baby since I am pregnant.
What kind of medication is it? Thank you.

Hsun, 30~39 year old female. Ask Date: 2019/12/28

Dr. Huang Jianzhong reply Obstetrics and Gynecology


At 34 weeks pregnant, I frequently experience nosebleeds, so I visited an ENT specialist.
During the examination, some medication was sprayed in my nose, and I noticed the name was "Wanose." I would like to ask the doctor if this medication will have any effects on my baby.

Answer: It will not affect the baby.
What kind of medication is it?
Answer: The main ingredients are Naphazoline nitrate and Chlorpheniramine maleate, which are used for the treatment of acute and chronic rhinitis, sinusitis, allergic rhinitis, and upper respiratory tract inflammation.

Reply Date: 2019/12/28

More Info


When considering the safety of medications during pregnancy, especially in the third trimester, it is crucial to evaluate both the active ingredients and the potential risks to the developing fetus. Wanose nasal spray contains two primary active ingredients: Naphazoline nitrate and Chlorpheniramine maleate.
Naphazoline is a sympathomimetic agent that acts as a vasoconstrictor, primarily used to relieve nasal congestion by constricting blood vessels in the nasal passages. Chlorpheniramine is an antihistamine that helps alleviate allergy symptoms such as sneezing, runny nose, and itching. Both of these components are commonly used in over-the-counter medications for nasal congestion and allergic reactions.

Regarding the safety of Wanose nasal spray during pregnancy, particularly at 34 weeks, the general consensus is that occasional use of such medications may not pose significant risks to the fetus. However, it is essential to consider a few factors:
1. FDA Classification: The FDA categorizes medications based on their safety during pregnancy. While specific classifications for Naphazoline and Chlorpheniramine may not be explicitly stated, many nasal sprays containing similar ingredients are often classified as Category C. This means that animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in pregnant women. Therefore, the potential benefits must be weighed against the risks.

2. Limited Systemic Absorption: When used as directed, nasal sprays typically have limited systemic absorption, meaning that only a small amount of the medication enters the bloodstream. This localized effect reduces the likelihood of significant fetal exposure compared to oral medications.

3. Consultation with Healthcare Providers: It is always advisable for pregnant women to consult their healthcare providers before using any medication, including over-the-counter products. Your healthcare provider can assess your specific situation, including the severity of your symptoms and any potential risks associated with the use of Wanose.

4. Alternative Treatments: If there are concerns about using Wanose, there may be alternative treatments available that are considered safer for use during pregnancy. Saline nasal sprays, for example, can help relieve nasal congestion without the risks associated with medicated sprays.

5. Monitoring for Side Effects: If you have already used Wanose nasal spray, monitor for any unusual symptoms or side effects. If you experience any adverse reactions or have concerns about your baby's health, it is crucial to contact your healthcare provider immediately.

In conclusion, while Wanose nasal spray may not pose a significant risk when used occasionally during pregnancy, it is essential to approach any medication with caution. Always consult with your healthcare provider to ensure that you are making informed decisions regarding your health and the health of your baby. They can provide personalized advice based on your medical history and current condition.

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