Blood in Urine: Insights on Bladder Cancer Concerns - Urology

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Suspected bladder cancer?


Hello Dr.
Du: I am 151675, following up on my question regarding "morning hematuria." In mid-December 2019, one morning I woke up with a dull sensation in my lower abdomen.
I went out for a brisk walk and slow jog for about 50 minutes.
After returning home, the feeling of fullness in my lower abdomen and genital area became more pronounced.
When I went to the bathroom to urinate, the urine was completely blood-red, and I felt a pressure sensation in my urethra as the urine passed.
Aside from the fullness and pressure, there was no pain like that of kidney stones (my previous experience involved severe pain in my lower back and abdomen).
I drank more water, and by around 9 AM, when I urinated again, the color was less bright red and more of a light brown.
After 11 AM, the urine was light yellow, and I could no longer see any red color.
That evening, I visited the hospital, where a urinalysis confirmed hematuria, but there were zero white blood cells.
An ultrasound of my kidneys showed no swelling, and an X-ray did not reveal any stones.
On the third day, I underwent the following tests: an intravenous pyelogram (IVP), which showed no tumors in the kidneys or urinary tract.
A cystoscopy revealed that the anterior urethra was intact, and there were no tumors in the bladder.
On the tenth day, I returned for the results of the urine cytology tests from the first two samples (the day of hematuria and the third day), which both showed no cancer cells, and the urine on the third day post-hematuria had no red blood cells.
On the fourteenth day, a urinalysis showed 0-2 white blood cells (-), 0-2 red blood cells, and negative for urine occult blood.
With zero white blood cells (indicating no urinary tract infection), normal IVP results, and no tumors found during cystoscopy (though a particularly prominent vascular distribution was noted, possibly indicating mucosal abrasion), it was inferred that a bladder stone may have abraded the bladder mucosa, leading to the hematuria.
Dr.
Du, I have a few questions and would appreciate your insights: (1) I am very curious—if it were a bladder stone, how could there be no severe pain like I experienced with kidney stones? Is this possible? (2) With gross hematuria and only a feeling of fullness during urination, in your clinical experience, have you encountered cases where bladder stones passed with hematuria but without severe pain? (3) After the cystoscopy on the third day post-hematuria, why was there no visible bleeding point? Is our mucosal cell repair that effective? (I always thought there would be clear signs of a bleeding wound.) (4) Given all the test results—ultrasound, X-ray, IVP, urine cytology, and cystoscopy—can I reasonably set aside concerns about bladder cancer? The doctors at the hospital were very kind and enthusiastic, but I was quite nervous at the time and forgot to clarify these questions, or perhaps the doctors explained things that I do not remember.
Therefore, I am reaching out to you for clarification.
Thank you very much, Dr.
Du.

Du Fen, 50~59 year old female. Ask Date: 2020/02/16

Dr. Du Shixi reply Urology


Hello: 1) Bladder stones do not necessarily cause lower back pain; stones can also form in the bladder.
If they form in the kidneys and then pass into the bladder, that is when lower back or abdominal pain may occur.
2) Yes.
3) It is possible; as long as there is no bleeding, it is difficult to determine the source of the bleeding.
4) Yes, as long as you regularly monitor the color of your urine, any discoloration should prompt a follow-up visit.
Additionally, return for a urine test in 2-3 months to check for the presence of occult blood.
Wishing you good health.

Reply Date: 2020/02/16

More Info


Blood in urine, or hematuria, can be a concerning symptom that often raises alarms about potential underlying conditions, including bladder cancer. However, based on your detailed account and the extensive evaluations you've undergone, it seems that the immediate fears regarding bladder cancer may be alleviated.

1. Bladder Stones and Pain: It is indeed possible to have bladder stones without experiencing the severe pain typically associated with kidney stones. The pain associated with kidney stones often arises from the stone moving through the ureter, which can cause significant stretching and irritation. In contrast, bladder stones may not always cause intense pain, especially if they are small or if they are not obstructing the flow of urine. The discomfort you experienced could be attributed to the irritation of the bladder wall rather than the presence of a stone itself.

2. Mild Discomfort with Blood in Urine: In clinical practice, it is not uncommon for patients to experience only mild discomfort or a sensation of pressure when passing blood in urine due to bladder stones. The absence of severe pain does not rule out the presence of stones; rather, it may indicate that the stones are not causing significant obstruction or irritation at that moment.

3. Self-Healing of Mucosal Cells: The human body has a remarkable ability to heal itself, including the mucosal lining of the bladder. It is possible for minor abrasions or irritations to heal quickly, which could explain why no active bleeding was observed during the cystoscopy performed three days after the initial episode of hematuria. The mucosal cells can regenerate rapidly, especially if the underlying cause of irritation (like a stone) has been resolved.

4. Reassurance Regarding Bladder Cancer: Given the comprehensive evaluations you have undergone—ultrasound, X-ray, IVP, urine cytology, and cystoscopy—all of which did not indicate the presence of tumors or significant abnormalities, it is reasonable to feel reassured about the absence of bladder cancer. The negative results from the urine cytology tests are particularly encouraging, as they are a strong indicator that cancerous cells are not present.

In summary, while blood in urine can be alarming, your case appears to have been thoroughly investigated, and the results suggest that there is no immediate cause for concern regarding bladder cancer. It is essential to maintain regular follow-ups with your healthcare provider, especially if you experience any recurrence of symptoms. Additionally, staying hydrated and following any preventive measures recommended by your doctor can help reduce the risk of future urinary issues.

If you continue to have concerns or if symptoms recur, seeking a second opinion or further evaluation from a urologist may provide additional peace of mind. It's always better to address any lingering doubts with a healthcare professional who can provide personalized advice based on your medical history and current health status.

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