Do Steroids and Antihistamines Affect Birth Control Pill Efficacy? - Obstetrics and Gynecology

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Drug interactions


Hello Doctor, I have been taking the oral contraceptive Yasmin for a year now, and my menstrual cycle has been regular every month.
However, I am currently undergoing treatment for dyshidrotic eczema and may need to take medications such as corticosteroids and antihistamines.
Will these medications affect the effectiveness of the oral contraceptive? Could they potentially reduce its efficacy? Additionally, I understand that the medications for treating athlete's foot and dyshidrotic eczema are different, but if I need to take medications for athlete's foot, will that also impact the effectiveness of the oral contraceptive? Thank you for your response.

Xiao Yu, 10~19 year old female. Ask Date: 2020/03/26

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact.
Wishing you good health.

Reply Date: 2020/03/26

More Info


When it comes to the interaction between steroids, antihistamines, and birth control pills, it's essential to understand how these medications work and their potential effects on contraceptive efficacy.
Firstly, regarding steroids, such as prednisone, they are not typically known to interfere with the effectiveness of oral contraceptives. Most studies and clinical guidelines indicate that common corticosteroids do not alter the metabolism of estrogen or progestin, the active components in many birth control pills. Therefore, if you are taking a steroid for a condition like dyshidrotic eczema (汗皰疹), it should not significantly impact the effectiveness of your birth control pill.

On the other hand, antihistamines are generally considered safe to use with birth control pills as well. Antihistamines, which are commonly used to treat allergies and conditions like eczema, do not have a known interaction that would reduce the efficacy of contraceptives. They work by blocking histamine receptors and do not affect the hormonal pathways involved in the action of birth control pills.

However, it is crucial to note that certain medications can affect the metabolism of birth control pills. For instance, some antibiotics and anti-seizure medications can reduce the effectiveness of hormonal contraceptives. This is primarily due to their ability to induce liver enzymes, which can increase the metabolism of contraceptive hormones, leading to decreased plasma levels and potentially reduced contraceptive efficacy.
In your case, if you are considering medications for treating athlete's foot (香港腳), it is essential to identify the specific medication. Some antifungal medications, particularly those that are systemic (taken orally), may have interactions with hormonal contraceptives. For example, medications like griseofulvin have been noted to potentially reduce the effectiveness of birth control pills. However, topical antifungal treatments typically do not have this effect.

In summary, while steroids and antihistamines are unlikely to affect the efficacy of your birth control pill, it is essential to be cautious with any new medications, especially systemic antifungals. Always consult with your healthcare provider about any new medications you plan to take, particularly if you are concerned about potential interactions with your contraceptive method. They can provide personalized advice based on your health history and the specific medications involved.
Lastly, if you are ever in doubt about the effectiveness of your birth control due to medication changes, consider using additional contraceptive methods, such as condoms, for added protection during that time. This approach can help ensure that you maintain effective contraception while managing your health conditions.

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Dr. Cao Guotao reply Obstetrics and Gynecology
Hello, it generally does not have an impact. Wishing you good health.

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