Doxycycline side effects / drug allergies
Hello, pharmacist.
I recently visited a dermatologist for acne treatment (it's my first time taking antibiotics; I haven't taken any medication for over five years).
The doctor prescribed Doxycycline 100 mg/capsule, to be taken twice daily, one capsule in the morning and one in the evening.
For the first two days, I took it after meals (my stomach isn't great...), and I felt fine.
However, on the third day, I forgot to take it after dinner and took it around 11 PM instead.
About 30 minutes later, I felt a bit dizzy and had a headache, along with significant nausea, rapid heartbeat, and shortness of breath, which led to vomiting (I vomited quite thoroughly, even bile, which was a bit bitter...
I never knew what bile looked like before...
then I drank water and vomited again...).
After vomiting, I felt less uncomfortable.
However, in the following days of taking the medication (after meals), I experienced some nausea, dizziness, and difficulty breathing.
I checked my blood pressure, and sometimes my heart rate was particularly fast, with systolic pressure around 90 (I've never had it drop below 100...).
Now, on day 13 of the medication, although the dizziness and breathing issues are less pronounced, I have developed soreness from my neck to my back and my arms feel sore and numb (strangely, this discomfort disappears about 4-5 hours after taking the medication...).
Currently, the area from my lower lip to my chin feels swollen and numb (without significant swelling), and I have mild oral ulcers.
In summary, I'm unsure whether I should continue taking the medication...
Although I can tolerate the current reactions, I want to complete the treatment (my follow-up appointment is on April 10...).
However, I'm very concerned about the possibility of an allergy, so I'm torn between the risk of an allergic reaction and the need to complete the treatment (worried about antibiotic resistance).
Therefore, I would like to ask for your advice: Should I continue taking the medication and monitor my symptoms, or can I reduce the dosage to one capsule a day, or take it with a stomach medication (I already ate a whole meal before taking the medication, but I still feel a bit nauseous)?
Yang Baobao, 20~29 year old female. Ask Date: 2020/03/28
Dr. Hou Fangmin reply Pharmacology
Hello Miss Yang,
The side effects of taking doxycycline include photosensitivity, so it is advisable to avoid direct sunlight during treatment.
Other dermatologic side effects may include erythema multiforme, dermatitis, as well as gastrointestinal issues such as nausea, vomiting, diarrhea, and inflammation of the tongue and stomach.
These side effects can vary from person to person, and not everyone will experience them.
Given that you are experiencing these side effects, it may be best to discontinue the medication.
Doxycycline is a commonly used antibiotic with a low incidence of allergic reactions, but it is possible that your body may react differently.
I recommend discussing this with your physician, explaining your allergic reactions to the medication, and considering whether to continue treatment.
Wishing you beauty, peace, and happiness!
Reply Date: 2020/03/28
More Info
When it comes to managing side effects and potential allergic reactions to Doxycycline, it is crucial to understand both the medication's profile and your individual response to it. Doxycycline is a tetracycline antibiotic commonly prescribed for acne treatment and other bacterial infections. While it is generally considered safe and effective, it can cause a range of side effects, and your experience suggests that you may be encountering some of these.
Firstly, the symptoms you described—nausea, vomiting, dizziness, and increased heart rate—are not uncommon with Doxycycline, especially if taken on an empty stomach or if there is a sensitivity to the medication. The fact that you vomited, particularly with bile, indicates that your stomach was reacting strongly to the medication. This can happen if the drug irritates the gastrointestinal tract, which is a known side effect of Doxycycline. Additionally, the dizziness and increased heart rate could be related to dehydration from vomiting or a reaction to the medication itself.
The muscle aches and tingling sensations you mentioned could also be side effects, although they are less common. Doxycycline can occasionally cause muscle and joint pain, and the tingling could be a sign of nerve irritation or a mild allergic reaction. The oral ulcers you are experiencing may also be a side effect, as Doxycycline can lead to mucosal irritation in some individuals.
Given your concerns about allergic reactions, it is essential to differentiate between side effects and true allergic responses. Allergic reactions typically involve symptoms such as hives, swelling, difficulty breathing, or severe gastrointestinal distress. If you are not experiencing these symptoms, it may be more likely that what you are experiencing is a side effect rather than an allergy. However, it is crucial to err on the side of caution.
Here are some recommendations for managing your situation:
1. Consult Your Physician: Before making any changes to your medication regimen, it is vital to discuss your symptoms with your prescribing physician. They can assess whether your symptoms are manageable or if they warrant discontinuation of the medication.
2. Consider Dose Adjustment: If your doctor agrees, you might discuss the possibility of reducing your dose to once daily instead of twice daily. This could help mitigate some of the side effects while still allowing you to complete your treatment.
3. Take with Food: Since you mentioned having a sensitive stomach, taking Doxycycline with food may help reduce gastrointestinal side effects. However, avoid dairy products, as they can interfere with the absorption of the medication.
4. Hydration: Ensure you are well-hydrated, especially if you have experienced vomiting. Dehydration can exacerbate dizziness and other symptoms.
5. Monitor Symptoms: Keep a detailed log of your symptoms, including when they occur and their severity. This information will be helpful for your doctor in determining the best course of action.
6. Avoid Sun Exposure: Doxycycline can increase sensitivity to sunlight, so be sure to protect your skin from sun exposure during treatment.
7. Consider Antacids: If you are experiencing significant stomach discomfort, discuss with your doctor the possibility of taking an antacid or a medication to protect your stomach lining, but ensure it does not interfere with Doxycycline absorption.
In conclusion, while Doxycycline is effective for treating acne, it can cause side effects that may be uncomfortable. Your health and safety are paramount, so it is essential to communicate openly with your healthcare provider about your experiences and concerns. They can provide tailored advice and adjustments to your treatment plan to ensure you can complete your course safely and effectively.
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