Drug Interactions with Emergency Contraceptives - Obstetrics and Gynecology

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Drug interactions of emergency contraceptive pills?


Hello doctor, I took the ELLA emergency contraceptive pill yesterday, and I'm wondering if my dizziness and lower abdominal pain today are side effects.
Can I take Tylenol? Will there be any drug interactions that could affect the efficacy of the emergency contraceptive? Thank you!

Niming, 20~29 year old female. Ask Date: 2020/03/30

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, generally it does not have an impact.
If you still feel unwell, it is advisable to see a physician.
Wishing you good health.

Reply Date: 2020/03/30

More Info


When it comes to understanding drug interactions, especially in the context of emergency contraceptives like ELLA (ulipristal acetate), it is crucial to consider both the pharmacological properties of the medications involved and their potential interactions. ELLA is a selective progesterone receptor modulator used for emergency contraception, and it works primarily by delaying ovulation.
Regarding your question about taking Paracetamol (known as acetaminophen in the U.S.) after taking ELLA, it is generally considered safe to use Paracetamol for pain relief. There are no known significant drug interactions between ELLA and Paracetamol that would compromise the effectiveness of the emergency contraceptive. Paracetamol is widely used for pain relief and fever reduction and does not affect the hormonal mechanisms of ELLA.

However, the symptoms you are experiencing, such as dizziness and lower abdominal pain, could be side effects of ELLA itself. Common side effects of ELLA include nausea, fatigue, headache, dizziness, and abdominal pain. These side effects are usually mild and temporary. If your symptoms persist or worsen, it is advisable to consult with a healthcare professional for further evaluation.

It is also important to note that while Paracetamol is safe to take with ELLA, you should always follow the recommended dosage instructions for any medication. Overuse of Paracetamol can lead to liver damage, so it is crucial to adhere to the guidelines provided on the packaging or by your healthcare provider.

In summary, taking Paracetamol after using ELLA should not lead to any drug interactions that would render the emergency contraceptive ineffective. However, if you have concerns about your symptoms or if they continue, it is best to seek medical advice. Always keep your healthcare provider informed about all medications you are taking, including over-the-counter drugs, to ensure safe and effective treatment.

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