Unresolved Urethral Discomfort: Seeking Answers for Persistent Symptoms - Urology

Share to:

Persistent urethral discomfort remains undiagnosed?


In late July 2018, I received oral sex at a massage parlor.
The next day, I experienced intense itching at the urethral opening of my penis, to the extent that I constantly scratched the area.
When I masturbated, I noticed a white discharge from the coronal sulcus.
These symptoms persisted for a month.
During this time, I consulted a physician and cannot recall the names of the medications I took.
I remember that a comprehensive urinalysis was performed, including tests for gonorrhea, chlamydia, ureaplasma, mycoplasma, trichomonas, and candida, all of which returned negative results.
I believe a bacterial culture was also done, which yielded no results.
After a month, the itching subsided, but I continued to have a strong odor from the glans of my penis and intermittent peeling until last week when I took probiotics, after which the odor and peeling suddenly disappeared.
In August 2019, I experienced a recurrence of sharp pain in the same area of the urethra, which spread along the entire urethra to the posterior urethra (between the anus and the scrotum).
This pain was severe, and I had no desire to scratch the area.
Sitting down would cause pain in the posterior urethra, and the pain intensified when I felt the urge to urinate.
I have not recovered since then, and I have undergone the same urinalysis, all of which were negative.
I would like to summarize that it is evident that the discomfort I experienced starting in 2018 is directly related to the oral sex, as symptoms appeared the very next day.
Aside from the aforementioned symptoms, I have not experienced typical symptoms such as painful urination, frequent urination, hematuria, hematospermia, rashes, or urethral discharge.
Since 2018, I have not engaged in any sexual activity.
I have the following questions:
1) Why did I experience significant itching clearly related to the aforementioned activity, yet laboratory tests showed no findings at that time? Even after experiencing severe pain in the past six months and undergoing further examinations, there were still no findings.
Is this normal?
2) Without typical symptoms of urethritis, could it be possible that the urethra is not infected? Could the cause be related to other nearby skin tissues?
3) What other tests can I undergo? Is it possible that the bacteria tested for are not the cause, and could there be other pathogens involved? Should a fungal culture also be performed? I suspect that something may have been overlooked during the past year and a half of examinations.
This painful symptom has troubled me for a long time and severely affects my quality of life; at times, the pain is so intense that I do not want to do anything.

Xiao Gao, 30~39 year old female. Ask Date: 2020/04/12

Dr. Du Shixi reply Urology


Hello: 1) It is quite common to have inconclusive test results, where only symptoms are present.
Sometimes, results can only be detected when symptoms first appear, and it may be even harder to detect after treatment (whether blood tests are involved, as some require blood draws).
Your symptoms currently resemble chronic prostatitis, which is also difficult to diagnose.
If confirmed, treatment will take a considerable amount of time.
2) Oral infections can be due to urethral or glans/foreskin infections.
They may exist separately or together.
3) Please visit a urology department for examination; some infections are easier to identify when tested at the onset of symptoms.
Wishing you good health.

Reply Date: 2020/04/12

More Info


Unresolved urethral discomfort can be a challenging and distressing condition, especially when it persists despite thorough medical evaluations. Based on your description, it appears that you have experienced a series of symptoms that began after a sexual encounter, which raises concerns about potential sexually transmitted infections (STIs) or other urogenital issues. However, the negative results from multiple tests can be perplexing and frustrating.

1. Why were there no findings despite clear symptoms?
The absence of detectable pathogens in laboratory tests does not necessarily mean that there is no underlying issue. Some infections, particularly those caused by atypical organisms or non-cultivable pathogens, may not be identified through standard testing. For example, certain viral infections or atypical bacteria may not be included in routine STI panels. Additionally, conditions such as urethral syndrome, which can present with symptoms similar to urethritis but without identifiable pathogens, may be a possibility. This syndrome can be caused by a variety of factors, including irritation, inflammation, or even psychological stress.

2. Could the issue be related to other skin or tissue problems?
Yes, it is entirely possible that the discomfort you are experiencing is not solely due to an infection of the urethra. Conditions such as contact dermatitis, balanitis (inflammation of the glans), or even skin conditions like psoriasis or eczema could contribute to the symptoms you describe. The presence of white discharge and the odor you mentioned may also indicate a fungal infection, such as candidiasis, which can sometimes be overlooked in standard tests.
3. What further evaluations can be done?
Given the complexity of your symptoms and the lack of definitive findings, it may be beneficial to pursue additional evaluations. A referral to a urologist who specializes in chronic pelvic pain or urethral disorders might provide more insight. They may recommend further tests, such as:
- Urethral swabs for specific pathogens that may not be included in standard panels.

- Fungal cultures to rule out yeast infections.

- Cystoscopy, a procedure that allows direct visualization of the urethra and bladder, which can help identify any structural abnormalities or lesions.

- Urine cytology to check for abnormal cells that might indicate other underlying issues.

4. Consideration of psychological factors:
Chronic pain and discomfort can also have psychological components. Stress, anxiety, and depression can exacerbate physical symptoms and create a cycle of discomfort. It may be beneficial to consider counseling or therapy as part of a comprehensive treatment plan.

5. Lifestyle and home remedies:
In addition to medical evaluations, consider lifestyle modifications that may alleviate symptoms. Staying hydrated, practicing good hygiene, and avoiding irritants (such as harsh soaps or personal care products) can be helpful. Additionally, probiotics, as you mentioned, may support gut and urogenital health, but it’s essential to discuss any supplements with your healthcare provider.

In conclusion, while the absence of identifiable pathogens in your tests is frustrating, it does not rule out the possibility of other conditions contributing to your symptoms. A thorough evaluation by a specialist, along with consideration of both physical and psychological factors, may lead to a better understanding of your discomfort and more effective management strategies. Your quality of life is important, and seeking comprehensive care is a crucial step in addressing your ongoing symptoms.

Similar Q&A

Persistent Urinary Discomfort: Seeking Solutions for Urethral Sensations

1. I have a frequent urination problem. 2. I feel like there is urine trapped inside my penis, which is very uncomfortable and affects my sleep. It feels like the sensation of needing to urinate at the urethral opening is constant. Doctor's solution: The doctor prescribed me...


Dr. Liu Mingyue reply Urology
Hello: Drink plenty of water, and your urine should be light yellow or clear. Avoid sitting for long periods, and engage in moderate exercise for 30 minutes each day. Wishing you good health!

[Read More] Persistent Urinary Discomfort: Seeking Solutions for Urethral Sensations


Unexplained Urethritis: Persistent Pain and Discomfort Solutions

Hello Dr. Wang, I have experienced a burning sensation during urination and pain at the urethral opening three times in the past two months. However, each time I have undergone urinalysis, the results have been normal, and no infection has been identified, yet I continue to exper...


Dr. Wang Weijie reply Internal Medicine
Dear Ms. Wu, Thank you for your letter. A urinary tract infection (UTI) occurs when bacteria invade the urinary system, leading to infection. Common symptoms include: 1. A burning sensation, pain, difficulty urinating, frequent urination, nocturia, cloudy urine, or hematuria dur...

[Read More] Unexplained Urethritis: Persistent Pain and Discomfort Solutions


Understanding Urethral Discomfort: Causes and Chronic Conditions Explained

Hello Dr. Du, I would like to ask about my condition. Four months ago, I sought medical attention due to frequent urination and discomfort in the urethra. However, my urinalysis came back normal, so the doctor only provided symptomatic treatment and did not prescribe antibiotics...


Dr. Du Shixi reply Urology
Hello, I would like to ask a few questions. Four months ago, I sought medical attention due to frequent urination and discomfort in the urethra. However, my urinalysis came back normal, so the doctor only provided symptomatic treatment and did not prescribe antibiotics. I still h...

[Read More] Understanding Urethral Discomfort: Causes and Chronic Conditions Explained


Understanding Urinary Issues: Insights on Symptoms and Causes

Hello Doctor, I am the inquirer with ID 176814. I apologize for having so many questions. Over the past few days, I have made the following observations: 1. I have not experienced any unusual sensations while urinating; my daily life has been normal, except that I have not had ...


Dr. Li Xinyi reply Urology
Excessive exercise, especially prolonged cycling or spinning, can also lead to urinary discomfort. Based on your description, it is unlikely that you have gonorrhea, as this infection typically presents with significant urethral pain and yellow urethral discharge, so testing for ...

[Read More] Understanding Urinary Issues: Insights on Symptoms and Causes


Related FAQ