Can You Take Probiotics While on Antibiotics for Pelvic Inflammatory Disease? - Obstetrics and Gynecology

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Is it safe to take probiotics while on antibiotics for pelvic inflammatory disease?


Hello Doctor, I have been taking antibiotics for pelvic inflammatory disease for over 20 days now.
My symptoms have significantly improved, and the doctor has determined that I can stop the medication after one more week.
The bacterial culture showed: Staphylococcus aureus / Streptococcus.
The antibiotics prescribed are: Metrozole (metronidazole) enteric-coated tablets, Clindamycin capsules, and antifungal vaginal suppositories.
My question is: Can I take probiotics (lactic acid bacteria) while on these antibiotics? Will it affect the efficacy of the antibiotics? Thank you very much for your response!

Ebbly, 30~39 year old female. Ask Date: 2020/04/16

Dr. Wu Xianghui reply Obstetrics and Gynecology


It is not recommended to take probiotics simultaneously with antibiotics, as antibiotics can kill both the intestinal bacteria and the probiotics being taken.

Reply Date: 2020/04/16

More Info


When dealing with pelvic inflammatory disease (PID) and the use of antibiotics, it's a common concern whether probiotics can be taken concurrently. The short answer is yes, you can take probiotics while on antibiotics, and doing so may actually be beneficial.

Antibiotics, such as the ones you mentioned—Metronidazole and Clindamycin—are effective in treating bacterial infections, but they can also disrupt the natural balance of bacteria in your gut and vaginal flora. This disruption can lead to side effects such as diarrhea and yeast infections, as the antibiotics may kill off beneficial bacteria along with the harmful ones. Probiotics, which are live microorganisms that provide health benefits when consumed in adequate amounts, can help restore this balance.

Research has shown that taking probiotics during and after a course of antibiotics can help mitigate some of the negative effects associated with antibiotic use. Probiotics can help replenish the beneficial bacteria that antibiotics may deplete, potentially reducing the risk of antibiotic-associated diarrhea and other complications. They can also support the immune system and may help prevent the overgrowth of harmful bacteria or yeast, such as Candida, which can occur when the normal flora is disrupted.

However, there are a few considerations to keep in mind:
1. Timing: To maximize the effectiveness of both antibiotics and probiotics, it's often recommended to take them at different times. For example, if you take your antibiotic in the morning, consider taking your probiotic in the evening. This helps ensure that the antibiotic does not kill the probiotic bacteria before they have a chance to provide their benefits.

2. Type of Probiotic: Not all probiotics are created equal. Look for probiotics that contain specific strains known to be effective, such as Lactobacillus and Bifidobacterium. These strains are often recommended for restoring vaginal and gut flora.

3. Consult Your Doctor: Always discuss with your healthcare provider before starting any new supplement, including probiotics, especially when you are on antibiotics. They can provide personalized advice based on your specific health needs and the antibiotics you are taking.

4. Duration of Use: Continue taking probiotics for a period after finishing your antibiotics to help restore your gut flora fully. This can help in preventing any potential recurrence of infections or imbalances.

In summary, taking probiotics while on antibiotics for pelvic inflammatory disease is not only safe but may also be beneficial in maintaining a healthy balance of bacteria in your body. Just be sure to space them out and consult with your healthcare provider for the best approach tailored to your situation.

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